FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007173853> ?p ?o ?g. }

• W2007173853 endingPage "104" @default.
• W2007173853 startingPage "97" @default.
• W2007173853 abstract "Addition of alpha-thrombin to quiescent IIC9 cells results in the activation of lipid-metabolizing enzymes associated with signal-transduction cascades. These enzymes include phosphatidylinositol (PI)-specific phospholipase C (PI-PLC), phosphatidylcholine (PC)-specific phospholipases C and D and phospholipase A2 (PLA2). Whereas the alpha-thrombin receptor has been shown to couple with PI-PLCs, it is not clear whether this receptor, or a putative second receptor, couples to one or more of the other phospholipases. In this report we determine whether the cloned receptor couples to all or a subset of these enzymes. We show that (i) an alpha-thrombin-receptor-activating peptide also elicits the above responses and (ii) addition of enterokinase to IIC9 cells, stably transfected with an alpha-thrombin receptor (enterokinase- responsive alpha-thrombin receptor, EKTR) containing an enterokinase cleavage site in place of an alpha-thrombin cleavage site, stimulates both PI and PC hydrolysis, including PLA2. Enterokinase also induces mitogenesis in the IIC9s transfected with EKTR. These results indicate that, in addition to initiating a mitogenic signalling cascade, the cloned alpha-thrombin receptor couples to enzymes involved in generating PC-derived, as well as PI-derived, second-messenger molecules in IIC9s. Additionally, using the cells transfected with EKTR, we further demonstrate that only activated, i. e. cleaved, receptors are desensitized." @default.
• W2007173853 created "2016-06-24" @default.
• W2007173853 creator A5012462653 @default.
• W2007173853 creator A5074337707 @default.
• W2007173853 creator A5089795750 @default.
• W2007173853 date "1998-12-17" @default.
• W2007173853 modified "2023-09-27" @default.
• W2007173853 title "Dual coupling of the α-thrombin receptor to signal-transduction pathways involving phosphatidylinositol and phosphatidylcholine metabolism" @default.
• W2007173853 cites W1490772051 @default.
• W2007173853 cites W1493051074 @default.
• W2007173853 cites W1497665885 @default.
• W2007173853 cites W1516430041 @default.
• W2007173853 cites W1522965874 @default.
• W2007173853 cites W1530505052 @default.
• W2007173853 cites W1545475398 @default.
• W2007173853 cites W1573232618 @default.
• W2007173853 cites W1577427687 @default.
• W2007173853 cites W1596104133 @default.
• W2007173853 cites W1603439931 @default.
• W2007173853 cites W1604527926 @default.
• W2007173853 cites W1658287483 @default.
• W2007173853 cites W1676701054 @default.
• W2007173853 cites W1964220124 @default.
• W2007173853 cites W1964456661 @default.
• W2007173853 cites W1967385667 @default.
• W2007173853 cites W1969420596 @default.
• W2007173853 cites W1984131924 @default.
• W2007173853 cites W1990500910 @default.
• W2007173853 cites W2022178125 @default.
• W2007173853 cites W2030995981 @default.
• W2007173853 cites W2032425418 @default.
• W2007173853 cites W2043401854 @default.
• W2007173853 cites W2043526402 @default.
• W2007173853 cites W2054634577 @default.
• W2007173853 cites W2078133735 @default.
• W2007173853 cites W2081753893 @default.
• W2007173853 cites W2094336459 @default.
• W2007173853 cites W2112701109 @default.
• W2007173853 cites W2126515466 @default.
• W2007173853 cites W2144444239 @default.
• W2007173853 cites W2153679072 @default.
• W2007173853 cites W2235684658 @default.
• W2007173853 cites W2443355694 @default.
• W2007173853 cites W2888511473 @default.
• W2007173853 doi "https://doi.org/10.1042/bj3370097" @default.
• W2007173853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1219941" @default.
• W2007173853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9854030" @default.
• W2007173853 hasPublicationYear "1998" @default.
• W2007173853 type Work @default.
• W2007173853 sameAs 2007173853 @default.
• W2007173853 citedByCount "8" @default.
• W2007173853 countsByYear W20071738532013 @default.
• W2007173853 crossrefType "journal-article" @default.
• W2007173853 hasAuthorship W2007173853A5012462653 @default.
• W2007173853 hasAuthorship W2007173853A5074337707 @default.
• W2007173853 hasAuthorship W2007173853A5089795750 @default.
• W2007173853 hasBestOaLocation W20071738532 @default.
• W2007173853 hasConcept C153911025 @default.
• W2007173853 hasConcept C170493617 @default.
• W2007173853 hasConcept C185592680 @default.
• W2007173853 hasConcept C201267052 @default.
• W2007173853 hasConcept C203014093 @default.
• W2007173853 hasConcept C2777292125 @default.
• W2007173853 hasConcept C2778597717 @default.
• W2007173853 hasConcept C2778886182 @default.
• W2007173853 hasConcept C2780610907 @default.
• W2007173853 hasConcept C55493867 @default.
• W2007173853 hasConcept C62478195 @default.
• W2007173853 hasConcept C78297661 @default.
• W2007173853 hasConcept C86803240 @default.
• W2007173853 hasConcept C89560881 @default.
• W2007173853 hasConcept C95444343 @default.
• W2007173853 hasConceptScore W2007173853C153911025 @default.
• W2007173853 hasConceptScore W2007173853C170493617 @default.
• W2007173853 hasConceptScore W2007173853C185592680 @default.
• W2007173853 hasConceptScore W2007173853C201267052 @default.
• W2007173853 hasConceptScore W2007173853C203014093 @default.
• W2007173853 hasConceptScore W2007173853C2777292125 @default.
• W2007173853 hasConceptScore W2007173853C2778597717 @default.
• W2007173853 hasConceptScore W2007173853C2778886182 @default.
• W2007173853 hasConceptScore W2007173853C2780610907 @default.
• W2007173853 hasConceptScore W2007173853C55493867 @default.
• W2007173853 hasConceptScore W2007173853C62478195 @default.
• W2007173853 hasConceptScore W2007173853C78297661 @default.
• W2007173853 hasConceptScore W2007173853C86803240 @default.
• W2007173853 hasConceptScore W2007173853C89560881 @default.
• W2007173853 hasConceptScore W2007173853C95444343 @default.
• W2007173853 hasIssue "1" @default.
• W2007173853 hasLocation W20071738531 @default.
• W2007173853 hasLocation W20071738532 @default.
• W2007173853 hasLocation W20071738533 @default.
• W2007173853 hasOpenAccess W2007173853 @default.
• W2007173853 hasPrimaryLocation W20071738531 @default.
• W2007173853 hasRelatedWork W150390702 @default.
• W2007173853 hasRelatedWork W1509335780 @default.
• W2007173853 hasRelatedWork W153731750 @default.
• W2007173853 hasRelatedWork W2007173853 @default.
• W2007173853 hasRelatedWork W2035430953 @default.

• next