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- W2007175222 abstract "2-Acetylaminofluorene (2-AAF) is a carcinogenic and mutagenic derivative of fluorene. It is used as a biochemical tool in the study of carcinogenesis. Studies have shown that it induces tumors in a number of species in the liver, bladder, and kidney. It is thought that 2-AAF–DNA adduct formation leads to mutation, and eventually tumor formation. The aim of this study was to examine the interactions of AAF with calf-thymus DNA in aqueous solution at physiological conditions, using constant DNA concentration (12.5 mM) and various AAF/polynucleotide (phosphate) ratios of 1/120, 1/80, 1/40, 1/20, 1/10, 1/5, 1/2, and 1/1. Fourier transform infrared and UV–visible spectroscopic methods and molecular modeling were used to determine the ligand binding mode, the binding constant, and the stability of AAF–DNA complexes in aqueous solution. Spectroscopic evidence showed both intercalation and external binding of AAF to DNA with an overall binding constant of KAAF–DNA=2.33×107 M−1. 2-AAF induced a partial B to A-DNA transition and DNA aggregation was observed at high AAF content." @default.
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- W2007175222 date "2011-11-01" @default.
- W2007175222 modified "2023-09-23" @default.
- W2007175222 title "Binding of 2-Acetylaminofluorene to DNA" @default.
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- W2007175222 doi "https://doi.org/10.1089/dna.2011.1229" @default.
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