FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007175311> ?p ?o ?g. }

• W2007175311 endingPage "192" @default.
• W2007175311 startingPage "182" @default.
• W2007175311 abstract "The oral cavity provides an entrance to the alimentary tract to serve as a protective barrier against harmful environmental stimuli. The oral mucosa is susceptible to injury because of its location; nonetheless, it has faster wound healing than the skin and less scar formation. However, the molecular pathways regulating this wound healing are unclear. Here, we show that transient receptor potential vanilloid 3 (TRPV3), a thermosensitive Ca2+-permeable channel, is more highly expressed in murine oral epithelia than in the skin by quantitative RT-PCR. We found that temperatures above 33°C activated TRPV3 and promoted oral epithelial cell proliferation. The proliferation rate in the oral epithelia of TRPV3 knockout (TRPV3KO) mice was less than that of wild-type (WT) mice. We investigated the contribution of TRPV3 to wound healing using a molar tooth extraction model and found that oral wound closure was delayed in TRPV3KO mice compared with that in WT mice. TRPV3 mRNA was up-regulated in wounded tissues, suggesting that TRPV3 may contribute to oral wound repair. We identified TRPV3 as an essential receptor in heat-induced oral epithelia proliferation and wound healing. Our findings suggest that TRPV3 activation could be a potential therapeutic target for wound healing in skin and oral mucosa.—Aijima, R., Wang, B., Takao, T., Mihara, H., Kashio, M., Ohsaki, Y., Zhang, J.-Q., Mizuno, A., Suzuki, M., Yamashita, Y., Masuko, S., Goto, M., Tominaga, M., Kido, M. A., The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia. FASEB J. 29, 182–192 (2015). www.fasebj.org" @default.
• W2007175311 created "2016-06-24" @default.
• W2007175311 creator A5001821504 @default.
• W2007175311 creator A5018446359 @default.
• W2007175311 creator A5021441721 @default.
• W2007175311 creator A5025840168 @default.
• W2007175311 creator A5029233710 @default.
• W2007175311 creator A5030099405 @default.
• W2007175311 creator A5040040696 @default.
• W2007175311 creator A5042401726 @default.
• W2007175311 creator A5046031701 @default.
• W2007175311 creator A5054635423 @default.
• W2007175311 creator A5069840694 @default.
• W2007175311 creator A5074653699 @default.
• W2007175311 creator A5081577782 @default.
• W2007175311 creator A5090827612 @default.
• W2007175311 date "2014-10-28" @default.
• W2007175311 modified "2023-10-15" @default.
• W2007175311 title "The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia" @default.
• W2007175311 cites W1511198581 @default.
• W2007175311 cites W1628719417 @default.
• W2007175311 cites W1946581668 @default.
• W2007175311 cites W1966176614 @default.
• W2007175311 cites W1966740493 @default.
• W2007175311 cites W1969124103 @default.
• W2007175311 cites W1970629236 @default.
• W2007175311 cites W1972801071 @default.
• W2007175311 cites W1975291617 @default.
• W2007175311 cites W1986073598 @default.
• W2007175311 cites W1999241959 @default.
• W2007175311 cites W2003380041 @default.
• W2007175311 cites W2009880851 @default.
• W2007175311 cites W2015128691 @default.
• W2007175311 cites W2023578856 @default.
• W2007175311 cites W2024583834 @default.
• W2007175311 cites W2027136734 @default.
• W2007175311 cites W2032785957 @default.
• W2007175311 cites W2036179916 @default.
• W2007175311 cites W2036537825 @default.
• W2007175311 cites W2038275562 @default.
• W2007175311 cites W2040933204 @default.
• W2007175311 cites W2043911313 @default.
• W2007175311 cites W2044037613 @default.
• W2007175311 cites W2044673085 @default.
• W2007175311 cites W2049680243 @default.
• W2007175311 cites W2057154060 @default.
• W2007175311 cites W2075586039 @default.
• W2007175311 cites W2082073167 @default.
• W2007175311 cites W2085293124 @default.
• W2007175311 cites W2085600594 @default.
• W2007175311 cites W2087172186 @default.
• W2007175311 cites W2087407796 @default.
• W2007175311 cites W2088314252 @default.
• W2007175311 cites W2094955398 @default.
• W2007175311 cites W2095495516 @default.
• W2007175311 cites W2096773815 @default.
• W2007175311 cites W2098510154 @default.
• W2007175311 cites W2100241249 @default.
• W2007175311 cites W2115785378 @default.
• W2007175311 cites W2116128726 @default.
• W2007175311 cites W2117896348 @default.
• W2007175311 cites W2117977784 @default.
• W2007175311 cites W2127012396 @default.
• W2007175311 cites W2129033989 @default.
• W2007175311 cites W2129220462 @default.
• W2007175311 cites W2138083852 @default.
• W2007175311 cites W2142822714 @default.
• W2007175311 cites W2142830401 @default.
• W2007175311 cites W2143347281 @default.
• W2007175311 cites W2146252487 @default.
• W2007175311 cites W2154063162 @default.
• W2007175311 cites W2162491067 @default.
• W2007175311 doi "https://doi.org/10.1096/fj.14-251314" @default.
• W2007175311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25351988" @default.
• W2007175311 hasPublicationYear "2014" @default.
• W2007175311 type Work @default.
• W2007175311 sameAs 2007175311 @default.
• W2007175311 citedByCount "68" @default.
• W2007175311 countsByYear W20071753112016 @default.
• W2007175311 countsByYear W20071753112017 @default.
• W2007175311 countsByYear W20071753112018 @default.
• W2007175311 countsByYear W20071753112019 @default.
• W2007175311 countsByYear W20071753112020 @default.
• W2007175311 countsByYear W20071753112021 @default.
• W2007175311 countsByYear W20071753112022 @default.
• W2007175311 countsByYear W20071753112023 @default.
• W2007175311 crossrefType "journal-article" @default.
• W2007175311 hasAuthorship W2007175311A5001821504 @default.
• W2007175311 hasAuthorship W2007175311A5018446359 @default.
• W2007175311 hasAuthorship W2007175311A5021441721 @default.
• W2007175311 hasAuthorship W2007175311A5025840168 @default.
• W2007175311 hasAuthorship W2007175311A5029233710 @default.
• W2007175311 hasAuthorship W2007175311A5030099405 @default.
• W2007175311 hasAuthorship W2007175311A5040040696 @default.
• W2007175311 hasAuthorship W2007175311A5042401726 @default.
• W2007175311 hasAuthorship W2007175311A5046031701 @default.
• W2007175311 hasAuthorship W2007175311A5054635423 @default.
• W2007175311 hasAuthorship W2007175311A5069840694 @default.

• next