FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007178124> ?p ?o ?g. }

• W2007178124 endingPage "193" @default.
• W2007178124 startingPage "184" @default.
• W2007178124 abstract "Cocaine abuse disrupts reward and homeostatic processes through diverse processes, including those involved in circadian clock regulation. Recently we showed that cocaine administration to mice disrupts nocturnal photic phase resetting of the suprachiasmatic (SCN) circadian clock, whereas administration during the day induces non-photic phase shifts. Importantly, the same effects are seen when cocaine is applied to the SCN in vitro, where it blocks photic-like (glutamate-induced) phase shifts at night and induces phase advances during the day. Furthermore, our previous data suggest that cocaine acts in the SCN by enhancing 5-HT signaling. For example, the in vitro actions of cocaine mimic those of 5-HT and are blocked by the 5-HT antagonist, metergoline, but not the dopamine receptor antagonist, fluphenazine. Although our data are consistent with cocaine acting through enhanced 5-HT signaling, the nonselective actions of cocaine as an antagonist of monoamine transporters raises the question of whether inhibition of the 5-HT transporter (SERT) is key to its circadian effects. Here we investigate this issue using transgenic mice expressing a SERT that exhibits normal 5-HT recognition and transport but significantly reduced cocaine potency (SERT Met172). Circadian patterns of SCN behavioral and neuronal activity did not differ between wild-type (WT) and SERT Met172 mice, nor did they differ in the ability of the 5-HT1A,2,7 receptor agonist, 8-OH-DPAT to reset SCN clock phase, consistent with the normal SERT expression and activity in the transgenic mice. However, (1) cocaine administration does not induce phase advances when administered in vivo or in vitro in SERT Met172 mice; (2) cocaine does not block photic or glutamate-induced phase shifts in SERT Met172 mice; and (3) cocaine does not induce long-term changes in free-running period in SERT Met172 mice. We conclude that SERT antagonism is required for the phase shifting of the SCN circadian clock induced by cocaine." @default.
• W2007178124 created "2016-06-24" @default.
• W2007178124 creator A5013584268 @default.
• W2007178124 creator A5018612310 @default.
• W2007178124 creator A5022425643 @default.
• W2007178124 creator A5031916777 @default.
• W2007178124 creator A5043820619 @default.
• W2007178124 creator A5056966239 @default.
• W2007178124 date "2014-09-01" @default.
• W2007178124 modified "2023-09-25" @default.
• W2007178124 title "Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN" @default.
• W2007178124 cites W1537372272 @default.
• W2007178124 cites W1549812476 @default.
• W2007178124 cites W1612131882 @default.
• W2007178124 cites W1948200758 @default.
• W2007178124 cites W1964259517 @default.
• W2007178124 cites W1971098142 @default.
• W2007178124 cites W1974726925 @default.
• W2007178124 cites W1976704662 @default.
• W2007178124 cites W1977732783 @default.
• W2007178124 cites W1978465685 @default.
• W2007178124 cites W1980154622 @default.
• W2007178124 cites W1986942981 @default.
• W2007178124 cites W1998352623 @default.
• W2007178124 cites W2002382519 @default.
• W2007178124 cites W2010739185 @default.
• W2007178124 cites W2021569361 @default.
• W2007178124 cites W2025431001 @default.
• W2007178124 cites W2027341865 @default.
• W2007178124 cites W2035206737 @default.
• W2007178124 cites W2035208607 @default.
• W2007178124 cites W2036616369 @default.
• W2007178124 cites W2045854014 @default.
• W2007178124 cites W2047155809 @default.
• W2007178124 cites W2060608999 @default.
• W2007178124 cites W2069343213 @default.
• W2007178124 cites W2070530252 @default.
• W2007178124 cites W2071794587 @default.
• W2007178124 cites W2082725211 @default.
• W2007178124 cites W2083855242 @default.
• W2007178124 cites W2085725696 @default.
• W2007178124 cites W2093281873 @default.
• W2007178124 cites W2093996714 @default.
• W2007178124 cites W2108304662 @default.
• W2007178124 cites W2108556733 @default.
• W2007178124 cites W2126644816 @default.
• W2007178124 cites W2131849270 @default.
• W2007178124 cites W2147352089 @default.
• W2007178124 cites W2154229467 @default.
• W2007178124 cites W2163715202 @default.
• W2007178124 cites W2165354719 @default.
• W2007178124 cites W2167027322 @default.
• W2007178124 cites W2169938627 @default.
• W2007178124 doi "https://doi.org/10.1016/j.neuroscience.2014.06.012" @default.
• W2007178124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4122660" @default.
• W2007178124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24950119" @default.
• W2007178124 hasPublicationYear "2014" @default.
• W2007178124 type Work @default.
• W2007178124 sameAs 2007178124 @default.
• W2007178124 citedByCount "26" @default.
• W2007178124 countsByYear W20071781242014 @default.
• W2007178124 countsByYear W20071781242015 @default.
• W2007178124 countsByYear W20071781242016 @default.
• W2007178124 countsByYear W20071781242017 @default.
• W2007178124 countsByYear W20071781242018 @default.
• W2007178124 countsByYear W20071781242019 @default.
• W2007178124 countsByYear W20071781242021 @default.
• W2007178124 countsByYear W20071781242022 @default.
• W2007178124 countsByYear W20071781242023 @default.
• W2007178124 crossrefType "journal-article" @default.
• W2007178124 hasAuthorship W2007178124A5013584268 @default.
• W2007178124 hasAuthorship W2007178124A5018612310 @default.
• W2007178124 hasAuthorship W2007178124A5022425643 @default.
• W2007178124 hasAuthorship W2007178124A5031916777 @default.
• W2007178124 hasAuthorship W2007178124A5043820619 @default.
• W2007178124 hasAuthorship W2007178124A5056966239 @default.
• W2007178124 hasBestOaLocation W20071781242 @default.
• W2007178124 hasConcept C121446783 @default.
• W2007178124 hasConcept C126322002 @default.
• W2007178124 hasConcept C134018914 @default.
• W2007178124 hasConcept C169760540 @default.
• W2007178124 hasConcept C170493617 @default.
• W2007178124 hasConcept C201176492 @default.
• W2007178124 hasConcept C2775864247 @default.
• W2007178124 hasConcept C2776120623 @default.
• W2007178124 hasConcept C2778938600 @default.
• W2007178124 hasConcept C2779317972 @default.
• W2007178124 hasConcept C38606739 @default.
• W2007178124 hasConcept C53910766 @default.
• W2007178124 hasConcept C71924100 @default.
• W2007178124 hasConcept C86803240 @default.
• W2007178124 hasConcept C98274493 @default.
• W2007178124 hasConceptScore W2007178124C121446783 @default.
• W2007178124 hasConceptScore W2007178124C126322002 @default.
• W2007178124 hasConceptScore W2007178124C134018914 @default.
• W2007178124 hasConceptScore W2007178124C169760540 @default.
• W2007178124 hasConceptScore W2007178124C170493617 @default.
• W2007178124 hasConceptScore W2007178124C201176492 @default.

• next