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• W2007178282 abstract "La néovascularisation cornéenne se définit comme l’apparition de vaisseaux au sein du stroma cornéen normalement avasculaire en réponse à une agression tissulaire aiguë ou chronique. Elle est responsable d’un afflux de cellules immunitaires au sein du stroma qui diminue les chances de succès des greffes de cornées. Ainsi, le ciblage thérapeutique des néovaisseaux constitue une piste récente de recherche visant à améliorer le pronostic des greffes de cornées. L’étude de l’efficacité des molécules anti-angiogéniques sur les néovaisseaux suppose donc que l’on puisse quantifier de manière objective l’importance de la néovascularisation avant puis après l’administration des médicaments. Dans la première partie de cette revue de la littérature, nous présentons successivement les examens qui permettent de documenter les néovaisseaux cornéens (photographies couleurs, angiographies du segment antérieur à la fluorescéine et au vert d’indocyanine, imagerie confocale in vivo). Nous abordons ensuite les méthodes de classification et de quantification de la néovascularisation cornéenne. Corneal neovascularization is defined as the invasion of vessels into the normally avascular clear corneal stroma, secondary to acute or chronic tissue injury. In addition to decreasing visual acuity, vascularity introduces circulating immune cells, reducing corneal immune privilege and the graft survival of subsequent keratoplasty. Thus, reducing neovascularization has become a recent therapeutic target in order to increase the success of corneal transplantation. Comparing the effects of antiangiogenic drugs assumes that we are able to quantify corneal neovascularization before and after treatment. In the first part of this literature review, we present the various methods to document neovessels (color photos, fluorescein and indocyanine green anterior segment angiography, in vivo confocal microscopy). Next, we report methods to classify and quantify corneal neovascularization." @default.
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• W2007178282 date "2013-10-01" @default.
• W2007178282 modified "2023-10-02" @default.
• W2007178282 title "Imagerie et quantification de la néovascularisation cornéenne" @default.
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• W2007178282 doi "https://doi.org/10.1016/j.jfo.2013.04.006" @default.
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