Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007178295> ?p ?o ?g. }
- W2007178295 endingPage "78" @default.
- W2007178295 startingPage "68" @default.
- W2007178295 abstract "The dietary consumption of high levels of soy has been linked to reduced risks for prostate cancer (PC) in Asians and vegetarians. In vitro studies have focused on the two most abundant isoflavones in soy, genistein and daidzein. However, daidzein is differentially metabolized by gut microflora in humans, yielding compounds with very different bioactivities and half-lives. Asians are significantly more likely to produce the metabolite equol than Caucasians, suggesting its role in the prevention of PC. We hypothesize that equol is a bioactive metabolite that exerts direct antiproliferative effects on prostatic epithelial cells.Benign and malignant prostatic epithelial cells were treated in vitro with equol, genistein, and daidzein by using the range of concentrations found in the prostatic fluids of Asians consuming soy. Growth and cell cycle distribution were analyzed over time.After 9 days of treatment, equol inhibited growth of benign human prostatic epithelial cells (PrEC) by 37% at 10(-6) M and 80% at 10(-5) M. Although genistein also had profound effects, daidzein appeared only one tenth as potent as equol. Equol and daidzein caused an accumulation of cells in G0/G1, whereas genistein arrested cells in G2/M. The isoflavonoids demonstrated differential effects on the established PC cell lines 22Rv1, LNCaP, LAPC-4, PC-3, and DU 145. PC-3 cells showed the greatest resistance.Equol is a biologically active metabolite of daidzein that has potent antiproliferative effects on benign and malignant prostatic epithelial cells at concentrations that can be obtained naturally through dietary soy consumption." @default.
- W2007178295 created "2016-06-24" @default.
- W2007178295 creator A5071742097 @default.
- W2007178295 creator A5082501489 @default.
- W2007178295 creator A5090299147 @default.
- W2007178295 date "2002-12-12" @default.
- W2007178295 modified "2023-10-17" @default.
- W2007178295 title "Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro" @default.
- W2007178295 cites W1567600191 @default.
- W2007178295 cites W1656644300 @default.
- W2007178295 cites W1676540962 @default.
- W2007178295 cites W1858959628 @default.
- W2007178295 cites W1886883565 @default.
- W2007178295 cites W1939905704 @default.
- W2007178295 cites W1964016705 @default.
- W2007178295 cites W1965674043 @default.
- W2007178295 cites W1969121458 @default.
- W2007178295 cites W1971498969 @default.
- W2007178295 cites W1977779461 @default.
- W2007178295 cites W1983809972 @default.
- W2007178295 cites W1988720181 @default.
- W2007178295 cites W1988859456 @default.
- W2007178295 cites W1989808698 @default.
- W2007178295 cites W1990287298 @default.
- W2007178295 cites W2000816881 @default.
- W2007178295 cites W2014321222 @default.
- W2007178295 cites W2018510674 @default.
- W2007178295 cites W2020115882 @default.
- W2007178295 cites W2024434952 @default.
- W2007178295 cites W2026159928 @default.
- W2007178295 cites W2030909150 @default.
- W2007178295 cites W2035016164 @default.
- W2007178295 cites W2039441471 @default.
- W2007178295 cites W2041679683 @default.
- W2007178295 cites W2045677809 @default.
- W2007178295 cites W2049919642 @default.
- W2007178295 cites W2051185023 @default.
- W2007178295 cites W2056817808 @default.
- W2007178295 cites W2058997806 @default.
- W2007178295 cites W2061805003 @default.
- W2007178295 cites W2072462480 @default.
- W2007178295 cites W2072749112 @default.
- W2007178295 cites W2073353512 @default.
- W2007178295 cites W2081021908 @default.
- W2007178295 cites W2081836794 @default.
- W2007178295 cites W2086742733 @default.
- W2007178295 cites W2088879795 @default.
- W2007178295 cites W2093658499 @default.
- W2007178295 cites W2098640833 @default.
- W2007178295 cites W2118282380 @default.
- W2007178295 cites W2131032307 @default.
- W2007178295 cites W2131962932 @default.
- W2007178295 cites W2136888691 @default.
- W2007178295 cites W2137330819 @default.
- W2007178295 cites W2143687970 @default.
- W2007178295 cites W2156293254 @default.
- W2007178295 cites W2161623422 @default.
- W2007178295 cites W2163113427 @default.
- W2007178295 cites W2174041920 @default.
- W2007178295 cites W3027494665 @default.
- W2007178295 cites W4247155715 @default.
- W2007178295 cites W62470977 @default.
- W2007178295 doi "https://doi.org/10.1002/pros.10137" @default.
- W2007178295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12481257" @default.
- W2007178295 hasPublicationYear "2002" @default.
- W2007178295 type Work @default.
- W2007178295 sameAs 2007178295 @default.
- W2007178295 citedByCount "131" @default.
- W2007178295 countsByYear W20071782952012 @default.
- W2007178295 countsByYear W20071782952013 @default.
- W2007178295 countsByYear W20071782952014 @default.
- W2007178295 countsByYear W20071782952015 @default.
- W2007178295 countsByYear W20071782952016 @default.
- W2007178295 countsByYear W20071782952017 @default.
- W2007178295 countsByYear W20071782952018 @default.
- W2007178295 countsByYear W20071782952019 @default.
- W2007178295 countsByYear W20071782952020 @default.
- W2007178295 countsByYear W20071782952021 @default.
- W2007178295 countsByYear W20071782952022 @default.
- W2007178295 countsByYear W20071782952023 @default.
- W2007178295 crossrefType "journal-article" @default.
- W2007178295 hasAuthorship W2007178295A5071742097 @default.
- W2007178295 hasAuthorship W2007178295A5082501489 @default.
- W2007178295 hasAuthorship W2007178295A5090299147 @default.
- W2007178295 hasConcept C121608353 @default.
- W2007178295 hasConcept C126322002 @default.
- W2007178295 hasConcept C134018914 @default.
- W2007178295 hasConcept C185592680 @default.
- W2007178295 hasConcept C202751555 @default.
- W2007178295 hasConcept C2776235491 @default.
- W2007178295 hasConcept C2777164284 @default.
- W2007178295 hasConcept C2777477808 @default.
- W2007178295 hasConcept C2778004101 @default.
- W2007178295 hasConcept C2778270713 @default.
- W2007178295 hasConcept C2778298627 @default.
- W2007178295 hasConcept C2778379183 @default.
- W2007178295 hasConcept C2779054382 @default.
- W2007178295 hasConcept C2779705811 @default.