FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007184421> ?p ?o ?g. }

• W2007184421 endingPage "108" @default.
• W2007184421 startingPage "101" @default.
• W2007184421 abstract "Background Although patients undergoing coronary stenting routinely receive dual antiplatelet treatment to reduce the risk of stent thrombosis, this undesired event still occurs. A suboptimal response to clopidogrel treatment (low responders) has been suggested to contribute to stent thrombosis. In the present study, platelet function profiles were assessed in patients undergoing coronary stenting receiving a standard 300-mg clopidogrel loading dose with the aim to identify low clopidogrel responders. Materials and methods Platelet aggregation was assessed by light transmittance aggregometry following 6 μM ADP stimuli in 48 patients before and 10 min, 4 and 24 h after receiving clopidogrel front-loading. Patients having ≥40% inhibition of platelet aggregation 24 h after clopidogrel administration were defined as normal responders, whereas those having <40% inhibition were low responders. Glycoprotein (GP) IIb/IIIa activation and P-selectin expression were assessed by whole blood flow cytometry following 2 μM ADP stimuli at the same time points. Platelet function profiles were compared between normal and low clopidogrel responders. Results Twenty-seven patients (56%) were normal responders and 21 (44%) low responders. Baseline GP IIb/IIIa activation was higher in low responders (74.6±16.6% vs. 58.2±24.5%, p=0.03). Although GP IIb/IIIa activation reduced following clopidogrel front-loading in both groups, it remained increased among low responders at 24 h (58.6±21.3% vs. 40.2±28.7%, p=0.05) and during the overall study time course (p=0.02). There were no differences in P-selectin expression. Conclusions A considerable proportion of patients have an early suboptimal response to a 300-mg clopidogrel loading dose. An increased GP IIb/IIIa activation before intervention may identify this group of patients suggesting the use of a more aggressive antithrombotic treatment in these individuals." @default.
• W2007184421 created "2016-06-24" @default.
• W2007184421 creator A5011188783 @default.
• W2007184421 creator A5012837780 @default.
• W2007184421 creator A5022649152 @default.
• W2007184421 creator A5026667861 @default.
• W2007184421 creator A5033895446 @default.
• W2007184421 creator A5037087807 @default.
• W2007184421 creator A5040418600 @default.
• W2007184421 creator A5052006329 @default.
• W2007184421 creator A5058585854 @default.
• W2007184421 creator A5063359323 @default.
• W2007184421 creator A5080359871 @default.
• W2007184421 creator A5081989604 @default.
• W2007184421 creator A5089318741 @default.
• W2007184421 creator A5091464960 @default.
• W2007184421 date "2005-01-01" @default.
• W2007184421 modified "2023-10-18" @default.
• W2007184421 title "Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting" @default.
• W2007184421 cites W1974238774 @default.
• W2007184421 cites W2001066812 @default.
• W2007184421 cites W2039527993 @default.
• W2007184421 cites W2045837139 @default.
• W2007184421 cites W2051729295 @default.
• W2007184421 cites W2053379248 @default.
• W2007184421 cites W2054962746 @default.
• W2007184421 cites W2055352066 @default.
• W2007184421 cites W2058848475 @default.
• W2007184421 cites W2065144339 @default.
• W2007184421 cites W2073449182 @default.
• W2007184421 cites W2084673482 @default.
• W2007184421 cites W2104595603 @default.
• W2007184421 cites W2110641306 @default.
• W2007184421 cites W2131470908 @default.
• W2007184421 cites W2138696762 @default.
• W2007184421 cites W2142107147 @default.
• W2007184421 cites W2145018871 @default.
• W2007184421 cites W2161043271 @default.
• W2007184421 cites W23524587 @default.
• W2007184421 cites W2748139581 @default.
• W2007184421 cites W4376848313 @default.
• W2007184421 doi "https://doi.org/10.1016/j.thromres.2004.07.007" @default.
• W2007184421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15567460" @default.
• W2007184421 hasPublicationYear "2005" @default.
• W2007184421 type Work @default.
• W2007184421 sameAs 2007184421 @default.
• W2007184421 citedByCount "169" @default.
• W2007184421 countsByYear W20071844212012 @default.
• W2007184421 countsByYear W20071844212013 @default.
• W2007184421 countsByYear W20071844212014 @default.
• W2007184421 countsByYear W20071844212015 @default.
• W2007184421 countsByYear W20071844212016 @default.
• W2007184421 countsByYear W20071844212017 @default.
• W2007184421 countsByYear W20071844212018 @default.
• W2007184421 countsByYear W20071844212019 @default.
• W2007184421 countsByYear W20071844212020 @default.
• W2007184421 countsByYear W20071844212021 @default.
• W2007184421 countsByYear W20071844212022 @default.
• W2007184421 crossrefType "journal-article" @default.
• W2007184421 hasAuthorship W2007184421A5011188783 @default.
• W2007184421 hasAuthorship W2007184421A5012837780 @default.
• W2007184421 hasAuthorship W2007184421A5022649152 @default.
• W2007184421 hasAuthorship W2007184421A5026667861 @default.
• W2007184421 hasAuthorship W2007184421A5033895446 @default.
• W2007184421 hasAuthorship W2007184421A5037087807 @default.
• W2007184421 hasAuthorship W2007184421A5040418600 @default.
• W2007184421 hasAuthorship W2007184421A5052006329 @default.
• W2007184421 hasAuthorship W2007184421A5058585854 @default.
• W2007184421 hasAuthorship W2007184421A5063359323 @default.
• W2007184421 hasAuthorship W2007184421A5080359871 @default.
• W2007184421 hasAuthorship W2007184421A5081989604 @default.
• W2007184421 hasAuthorship W2007184421A5089318741 @default.
• W2007184421 hasAuthorship W2007184421A5091464960 @default.
• W2007184421 hasConcept C126322002 @default.
• W2007184421 hasConcept C164705383 @default.
• W2007184421 hasConcept C2777628954 @default.
• W2007184421 hasConcept C2777698277 @default.
• W2007184421 hasConcept C2777849778 @default.
• W2007184421 hasConcept C2778283817 @default.
• W2007184421 hasConcept C2778583881 @default.
• W2007184421 hasConcept C2780868729 @default.
• W2007184421 hasConcept C2780911114 @default.
• W2007184421 hasConcept C3018697912 @default.
• W2007184421 hasConcept C35294091 @default.
• W2007184421 hasConcept C500558357 @default.
• W2007184421 hasConcept C71924100 @default.
• W2007184421 hasConcept C89560881 @default.
• W2007184421 hasConceptScore W2007184421C126322002 @default.
• W2007184421 hasConceptScore W2007184421C164705383 @default.
• W2007184421 hasConceptScore W2007184421C2777628954 @default.
• W2007184421 hasConceptScore W2007184421C2777698277 @default.
• W2007184421 hasConceptScore W2007184421C2777849778 @default.
• W2007184421 hasConceptScore W2007184421C2778283817 @default.
• W2007184421 hasConceptScore W2007184421C2778583881 @default.
• W2007184421 hasConceptScore W2007184421C2780868729 @default.
• W2007184421 hasConceptScore W2007184421C2780911114 @default.
• W2007184421 hasConceptScore W2007184421C3018697912 @default.
• W2007184421 hasConceptScore W2007184421C35294091 @default.

• next