Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007187811> ?p ?o ?g. }
- W2007187811 endingPage "20083" @default.
- W2007187811 startingPage "20078" @default.
- W2007187811 abstract "Myoferlin (MYOF) is a member of the evolutionarily conserved ferlin family of proteins, noted for their role in a variety of membrane processes, including endocytosis, repair, and vesicular transport. Notably, ferlins are implicated in Caenorhabditis elegans sperm motility (Fer-1), mammalian skeletal muscle development and repair (MYOF and dysferlin), and presynaptic transmission in the auditory system (otoferlin). In this paper, we demonstrate that MYOF plays a previously unrecognized role in cancer cell invasion, using a combination of mathematical modeling and in vitro experiments. Using a real-time impedance-based invasion assay (xCELLigence), we have shown that lentiviral-based knockdown of MYOF significantly reduced invasion of MDA-MB-231 breast cancer cells in Matrigel bioassays. Based on these experimental data, we developed a partial differential equation model of MYOF effects on cancer cell invasion, which we used to generate mechanistic hypotheses. The mathematical model predictions revealed that matrix metalloproteinases (MMPs) may play a key role in modulating this invasive property, which was supported by experimental data using quantitative RT-PCR screens. These results suggest that MYOF may be a promising target for biomarkers or drug target for metastatic cancer diagnosis and therapy, perhaps mediated through MMPs." @default.
- W2007187811 created "2016-06-24" @default.
- W2007187811 creator A5000368756 @default.
- W2007187811 creator A5026623974 @default.
- W2007187811 creator A5041782217 @default.
- W2007187811 creator A5051924511 @default.
- W2007187811 creator A5054769385 @default.
- W2007187811 creator A5082559641 @default.
- W2007187811 date "2011-11-30" @default.
- W2007187811 modified "2023-10-14" @default.
- W2007187811 title "Mechanistic modeling of the effects of myoferlin on tumor cell invasion" @default.
- W2007187811 cites W1551193713 @default.
- W2007187811 cites W1563841899 @default.
- W2007187811 cites W1964081206 @default.
- W2007187811 cites W1964162087 @default.
- W2007187811 cites W1965214685 @default.
- W2007187811 cites W1969974695 @default.
- W2007187811 cites W1977735548 @default.
- W2007187811 cites W1983351039 @default.
- W2007187811 cites W1986553481 @default.
- W2007187811 cites W2000602441 @default.
- W2007187811 cites W2017454736 @default.
- W2007187811 cites W2019133907 @default.
- W2007187811 cites W2030010320 @default.
- W2007187811 cites W2033577716 @default.
- W2007187811 cites W2053023842 @default.
- W2007187811 cites W2055554786 @default.
- W2007187811 cites W2056685208 @default.
- W2007187811 cites W2066363077 @default.
- W2007187811 cites W2068034489 @default.
- W2007187811 cites W2068832495 @default.
- W2007187811 cites W2071162640 @default.
- W2007187811 cites W2078502914 @default.
- W2007187811 cites W2083023384 @default.
- W2007187811 cites W2101161126 @default.
- W2007187811 cites W2105788894 @default.
- W2007187811 cites W2106324853 @default.
- W2007187811 cites W2115254768 @default.
- W2007187811 cites W2128985829 @default.
- W2007187811 cites W2137983743 @default.
- W2007187811 cites W2145002455 @default.
- W2007187811 cites W2145657329 @default.
- W2007187811 cites W2146099965 @default.
- W2007187811 cites W2146678830 @default.
- W2007187811 cites W2150020842 @default.
- W2007187811 cites W2154473174 @default.
- W2007187811 cites W2154754261 @default.
- W2007187811 cites W2157141484 @default.
- W2007187811 cites W2161093636 @default.
- W2007187811 cites W2163924299 @default.
- W2007187811 doi "https://doi.org/10.1073/pnas.1116327108" @default.
- W2007187811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3250187" @default.
- W2007187811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22135466" @default.
- W2007187811 hasPublicationYear "2011" @default.
- W2007187811 type Work @default.
- W2007187811 sameAs 2007187811 @default.
- W2007187811 citedByCount "80" @default.
- W2007187811 countsByYear W20071878112012 @default.
- W2007187811 countsByYear W20071878112013 @default.
- W2007187811 countsByYear W20071878112014 @default.
- W2007187811 countsByYear W20071878112015 @default.
- W2007187811 countsByYear W20071878112016 @default.
- W2007187811 countsByYear W20071878112017 @default.
- W2007187811 countsByYear W20071878112018 @default.
- W2007187811 countsByYear W20071878112019 @default.
- W2007187811 countsByYear W20071878112020 @default.
- W2007187811 countsByYear W20071878112021 @default.
- W2007187811 countsByYear W20071878112022 @default.
- W2007187811 countsByYear W20071878112023 @default.
- W2007187811 crossrefType "journal-article" @default.
- W2007187811 hasAuthorship W2007187811A5000368756 @default.
- W2007187811 hasAuthorship W2007187811A5026623974 @default.
- W2007187811 hasAuthorship W2007187811A5041782217 @default.
- W2007187811 hasAuthorship W2007187811A5051924511 @default.
- W2007187811 hasAuthorship W2007187811A5054769385 @default.
- W2007187811 hasAuthorship W2007187811A5082559641 @default.
- W2007187811 hasBestOaLocation W20071878111 @default.
- W2007187811 hasConcept C104317684 @default.
- W2007187811 hasConcept C109523444 @default.
- W2007187811 hasConcept C11957725 @default.
- W2007187811 hasConcept C121608353 @default.
- W2007187811 hasConcept C1491633281 @default.
- W2007187811 hasConcept C173396325 @default.
- W2007187811 hasConcept C2778608917 @default.
- W2007187811 hasConcept C2778944004 @default.
- W2007187811 hasConcept C2779013556 @default.
- W2007187811 hasConcept C28005876 @default.
- W2007187811 hasConcept C502942594 @default.
- W2007187811 hasConcept C54355233 @default.
- W2007187811 hasConcept C58207958 @default.
- W2007187811 hasConcept C81885089 @default.
- W2007187811 hasConcept C86803240 @default.
- W2007187811 hasConcept C95444343 @default.
- W2007187811 hasConcept C96232424 @default.
- W2007187811 hasConceptScore W2007187811C104317684 @default.
- W2007187811 hasConceptScore W2007187811C109523444 @default.
- W2007187811 hasConceptScore W2007187811C11957725 @default.
- W2007187811 hasConceptScore W2007187811C121608353 @default.