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- W2007189817 abstract "Background and aim: EBV infection and post-transplant lymphoproliferative disease (PTLD) are closely linked, but the contribution of EBV to graft dysfunction (GD) has not been clearly reported. The aim was to evaluate the impact of EBV infection on GD post-liver transplantation (LT). Methods: Retrospective study of children who underwent LT between 2004-2008. EBV status (serology and PCR) was determined before LT at 6 and 12 months (m) or if GD was suspected. EBV positivity before LT was based on IgG and EBNA-EBV (ELISA). Primary infection(PI)/reactivation were diagnosed by VCA-IgM or PCR-EBV+ (Real-time PCR). GD was accessed by cytolysis/cholestasis markers and/or histology. Results: Forty children received a first LT and 32 were included. The mean age was 6 years (5m-15y) and mean follow-up was 3y. Indications for LT were: biliary atresia(10), metabolic disease(8), alpha1-antitrypsin deficiency(5), others(9). Before LT, 14 children, mean age 9.6y, were EBV-positive (group A) and 18 (56%), mean age 3.2y, EBV-negative (group B). In group A there was no reactivation and in group B, 12 (67%) had PI. GD occurred in 71% of group A vs 56% in group B (p = 0.471). EBV infection had no impact on the graft in 5/12 children. 7/12 had another etiology for GD. Immunosuppression (ISS) was decreased in 6 (2 with suspected PTLD) with GD improvement in 1 and late rejection in 1. Conclusions: EBV PI occurred in 67% of children after LT. Half experienced GD, but improvement was not associated with reduced ISS. Isolated EBV infection had a minor impact on GD." @default.
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- W2007189817 date "2010-11-01" @default.
- W2007189817 modified "2023-09-26" @default.
- W2007189817 title "278 Epstein-Barr Virus Infection and Graft Dysfunction in the First Year Post-Liver Transplantation" @default.
- W2007189817 doi "https://doi.org/10.1203/00006450-201011001-00278" @default.
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