FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007193289> ?p ?o ?g. }

• W2007193289 endingPage "47" @default.
• W2007193289 startingPage "38" @default.
• W2007193289 abstract "The intestinal mucosa represents a challenging environment for CD8+ T cells, which must tolerate nutrient antigens and commensal microorganisms while responding efficiently to pathogens. Consequently, specific regulatory mechanisms apply for CD8+ T cells in the intestinal environment, which should also be reflected in a tissue-specific gene expression profile of these cells. This study investigates whether such tissue-specific gene expression can be observed in CD8+ T cells primed during bacterial infection. To identify intestine-specific gene expression in conventional CD8alphabeta+ T cells, mice were infected with Listeria monocytogenes expressing ovalbumin (LmOVA). Using OVA257-264 tetramers, specific CD8+ T cells were sorted from spleen, liver and the small intestinal mucosa, and RNA samples from these cells were compared using microarrays. This approach allowed the identification of differences in gene expression in a highly defined CD8+ T-cell population with identical antigen specificity generated during infection. One group of genes with reduced expression in the intestinal mucosa comprised members of the C-type lectin-like natural killer receptor (NKR) family. Fluorescence-activated cell sorting analysis was used to assess protein expression of NKR. NKR expression on CD8+ T cells from the intestinal mucosa was dependent on the route of listeria application and consequently on the site of T-cell priming. Retinoic acid influenced NKR expression consistent with an imprinting of the NKR expression profile in intestine-associated lymphoid tissues. In contrast, NKR expression was largely independent from intestinal flora. Our results demonstrate that in the intestinal mucosa, conventional CD8alphabeta+ T cells lack NKR expression and thereby lose responsiveness to NKR ligands, which otherwise could possibly cause adverse activation or inhibition of T cells in this environment." @default.
• W2007193289 created "2016-06-24" @default.
• W2007193289 creator A5014291323 @default.
• W2007193289 creator A5024513852 @default.
• W2007193289 creator A5026681835 @default.
• W2007193289 creator A5047638165 @default.
• W2007193289 creator A5061093360 @default.
• W2007193289 creator A5073346179 @default.
• W2007193289 date "2008-09-01" @default.
• W2007193289 modified "2023-10-18" @default.
• W2007193289 title "Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine" @default.
• W2007193289 cites W1503807991 @default.
• W2007193289 cites W1515040786 @default.
• W2007193289 cites W1518556257 @default.
• W2007193289 cites W1557947969 @default.
• W2007193289 cites W1568984819 @default.
• W2007193289 cites W1576002354 @default.
• W2007193289 cites W1595098530 @default.
• W2007193289 cites W1774358685 @default.
• W2007193289 cites W1908616178 @default.
• W2007193289 cites W1931750338 @default.
• W2007193289 cites W1934719640 @default.
• W2007193289 cites W1968880209 @default.
• W2007193289 cites W1969464492 @default.
• W2007193289 cites W1980776953 @default.
• W2007193289 cites W1981752846 @default.
• W2007193289 cites W2004424160 @default.
• W2007193289 cites W2010011171 @default.
• W2007193289 cites W2010749951 @default.
• W2007193289 cites W2017773433 @default.
• W2007193289 cites W2022609860 @default.
• W2007193289 cites W2031551895 @default.
• W2007193289 cites W2033018213 @default.
• W2007193289 cites W2037057992 @default.
• W2007193289 cites W2056645320 @default.
• W2007193289 cites W2063221590 @default.
• W2007193289 cites W2063429059 @default.
• W2007193289 cites W2064920472 @default.
• W2007193289 cites W2079683856 @default.
• W2007193289 cites W2085005209 @default.
• W2007193289 cites W2090487140 @default.
• W2007193289 cites W2096742771 @default.
• W2007193289 cites W2100433064 @default.
• W2007193289 cites W2104412491 @default.
• W2007193289 cites W2111180521 @default.
• W2007193289 cites W2123307454 @default.
• W2007193289 cites W2125224862 @default.
• W2007193289 cites W2128452798 @default.
• W2007193289 cites W2129035006 @default.
• W2007193289 cites W2131625721 @default.
• W2007193289 cites W2132411790 @default.
• W2007193289 cites W2134824958 @default.
• W2007193289 cites W2144277936 @default.
• W2007193289 cites W2145436256 @default.
• W2007193289 cites W2149291946 @default.
• W2007193289 cites W2150943213 @default.
• W2007193289 cites W2155344565 @default.
• W2007193289 cites W2165547934 @default.
• W2007193289 cites W2171709048 @default.
• W2007193289 cites W4256399029 @default.
• W2007193289 doi "https://doi.org/10.1111/j.1365-2567.2008.02817.x" @default.
• W2007193289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2526258" @default.
• W2007193289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18298548" @default.
• W2007193289 hasPublicationYear "2008" @default.
• W2007193289 type Work @default.
• W2007193289 sameAs 2007193289 @default.
• W2007193289 citedByCount "3" @default.
• W2007193289 countsByYear W20071932892014 @default.
• W2007193289 crossrefType "journal-article" @default.
• W2007193289 hasAuthorship W2007193289A5014291323 @default.
• W2007193289 hasAuthorship W2007193289A5024513852 @default.
• W2007193289 hasAuthorship W2007193289A5026681835 @default.
• W2007193289 hasAuthorship W2007193289A5047638165 @default.
• W2007193289 hasAuthorship W2007193289A5061093360 @default.
• W2007193289 hasAuthorship W2007193289A5073346179 @default.
• W2007193289 hasBestOaLocation W20071932892 @default.
• W2007193289 hasConcept C104317684 @default.
• W2007193289 hasConcept C126322002 @default.
• W2007193289 hasConcept C129374314 @default.
• W2007193289 hasConcept C139563560 @default.
• W2007193289 hasConcept C147483822 @default.
• W2007193289 hasConcept C150194340 @default.
• W2007193289 hasConcept C153911025 @default.
• W2007193289 hasConcept C154317977 @default.
• W2007193289 hasConcept C167672396 @default.
• W2007193289 hasConcept C202751555 @default.
• W2007193289 hasConcept C203014093 @default.
• W2007193289 hasConcept C2779118045 @default.
• W2007193289 hasConcept C3019368612 @default.
• W2007193289 hasConcept C55493867 @default.
• W2007193289 hasConcept C71924100 @default.
• W2007193289 hasConcept C86803240 @default.
• W2007193289 hasConceptScore W2007193289C104317684 @default.
• W2007193289 hasConceptScore W2007193289C126322002 @default.
• W2007193289 hasConceptScore W2007193289C129374314 @default.
• W2007193289 hasConceptScore W2007193289C139563560 @default.
• W2007193289 hasConceptScore W2007193289C147483822 @default.
• W2007193289 hasConceptScore W2007193289C150194340 @default.

• next