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- W2007198624 abstract "The objective of this study was to determine the maternal and fetal effects of West Nile Virus (WNV) infection during pregnancy. Current enrollment for this investigation includes 15 cases retrospectively identified in 2003 and 2004 through a CDC registry and 21 cases prospectively identified in 2005 and 2006. Controls are being recruited for comparison to the prospective group. Maternal sera and cord blood on all participants is being tested for WNV-specific IgM and IgG antibodies, with confirmation of WNV through plaque reduction neutralization testing (PRNT). Information on maternal socioeconomic factors, prenatal history, birth history, newborn examinations and follow-up examinations are being collected. Ophthalmologic examinations and Bayley developmental assessments are also being performed on children up to 36 months of age. Thus far, pregnant women with a symptomatic WNV illness have presented with fever, rash, headache, meningitis, encephalitis, or flaccid paralysis. Of the 36 WNV cases, there were 7, 15, and 14 infections in the 1st, 2nd and 3rd trimesters, respectively. Four (11%) children were born with birth defects (aortic coarctation, cleft palate, umbilical hernia, torticollis). However, all mothers of these children were infected in the second and third trimester. WNV-specific IgM antibodies were detected in the sera of two newborns. One was born with aortic coarctation and a rash but is developing normally; the other was stillborn at 31 weeks to a mother infected 4 weeks earlier. No microcephaly or growth delay was observed among babies in the retrospective group. No chorioretinitis or cataracts were detected, and Bayley developmental assessments were at age level. Nearly all infected mothers delivered at term, and birth complications occurred at expected rates. Maternal WNV infection does not appear to increase pregnancy complications or adversely affect growth and developmental outcomes of their children." @default.
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- W2007198624 date "2007-12-01" @default.
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- W2007198624 title "649: West Nile Virus and pregnancy outcomes" @default.
- W2007198624 doi "https://doi.org/10.1016/j.ajog.2007.10.676" @default.
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