Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007200101> ?p ?o ?g. }
- W2007200101 endingPage "89" @default.
- W2007200101 startingPage "84" @default.
- W2007200101 abstract "Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing pancreatic beta cells. There is now mounting evidence that pro-inflammatory pathways, which are mediated by T cells that secrete IL-17 and IFN-γ, play a critical role in the loss of beta cells. These data suggest that blockade of T cells that secrete IL-17 and IFN-γ may halt or reverse disease in subjects with recent-onset T1D. Agents to facilitate this approach are currently in clinical use. Ustekinumab, a humanized monoclonal antibody that targets the shared p40 subunit of IL-12 and IL-23, has been used for the treatment of psoriasis, an indication for which it has proven to be safe and effective. In this review, we summarize the evidence that supports a combined pathogenic role of IL-17 and IFN-γ in the development of T1D, with the aim of providing a rationale for testing agents such as ustekinumab for the treatment of T1D." @default.
- W2007200101 created "2016-06-24" @default.
- W2007200101 creator A5023184639 @default.
- W2007200101 creator A5046835137 @default.
- W2007200101 creator A5088110704 @default.
- W2007200101 date "2014-09-01" @default.
- W2007200101 modified "2023-10-13" @default.
- W2007200101 title "Targeting the IL-17/IFN-γ axis as a potential new clinical therapy for type 1 diabetes" @default.
- W2007200101 cites W1530509485 @default.
- W2007200101 cites W1554901867 @default.
- W2007200101 cites W1964104789 @default.
- W2007200101 cites W1964787243 @default.
- W2007200101 cites W1971708477 @default.
- W2007200101 cites W1977695959 @default.
- W2007200101 cites W1992452472 @default.
- W2007200101 cites W1996904143 @default.
- W2007200101 cites W1997959717 @default.
- W2007200101 cites W2012077729 @default.
- W2007200101 cites W2013129557 @default.
- W2007200101 cites W2019338701 @default.
- W2007200101 cites W2031111219 @default.
- W2007200101 cites W2048990853 @default.
- W2007200101 cites W2062572904 @default.
- W2007200101 cites W2072449713 @default.
- W2007200101 cites W2080090843 @default.
- W2007200101 cites W2086814528 @default.
- W2007200101 cites W2089749009 @default.
- W2007200101 cites W2091120768 @default.
- W2007200101 cites W2098954537 @default.
- W2007200101 cites W2104298924 @default.
- W2007200101 cites W2106107076 @default.
- W2007200101 cites W2106471879 @default.
- W2007200101 cites W2109121747 @default.
- W2007200101 cites W2110641805 @default.
- W2007200101 cites W2112128505 @default.
- W2007200101 cites W2118727041 @default.
- W2007200101 cites W2120361612 @default.
- W2007200101 cites W2125380322 @default.
- W2007200101 cites W2126298669 @default.
- W2007200101 cites W2127997822 @default.
- W2007200101 cites W2135201054 @default.
- W2007200101 cites W2141016525 @default.
- W2007200101 cites W2141723416 @default.
- W2007200101 cites W2151991135 @default.
- W2007200101 cites W2163101795 @default.
- W2007200101 cites W2163437199 @default.
- W2007200101 cites W2322390243 @default.
- W2007200101 doi "https://doi.org/10.1016/j.clim.2014.06.006" @default.
- W2007200101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24947953" @default.
- W2007200101 hasPublicationYear "2014" @default.
- W2007200101 type Work @default.
- W2007200101 sameAs 2007200101 @default.
- W2007200101 citedByCount "37" @default.
- W2007200101 countsByYear W20072001012014 @default.
- W2007200101 countsByYear W20072001012015 @default.
- W2007200101 countsByYear W20072001012016 @default.
- W2007200101 countsByYear W20072001012017 @default.
- W2007200101 countsByYear W20072001012018 @default.
- W2007200101 countsByYear W20072001012019 @default.
- W2007200101 countsByYear W20072001012020 @default.
- W2007200101 countsByYear W20072001012021 @default.
- W2007200101 countsByYear W20072001012022 @default.
- W2007200101 countsByYear W20072001012023 @default.
- W2007200101 crossrefType "journal-article" @default.
- W2007200101 hasAuthorship W2007200101A5023184639 @default.
- W2007200101 hasAuthorship W2007200101A5046835137 @default.
- W2007200101 hasAuthorship W2007200101A5088110704 @default.
- W2007200101 hasConcept C126322002 @default.
- W2007200101 hasConcept C134018914 @default.
- W2007200101 hasConcept C156730664 @default.
- W2007200101 hasConcept C159654299 @default.
- W2007200101 hasConcept C163864487 @default.
- W2007200101 hasConcept C170493617 @default.
- W2007200101 hasConcept C17991360 @default.
- W2007200101 hasConcept C203014093 @default.
- W2007200101 hasConcept C2777138892 @default.
- W2007200101 hasConcept C2777180221 @default.
- W2007200101 hasConcept C2778468042 @default.
- W2007200101 hasConcept C2778690821 @default.
- W2007200101 hasConcept C2778975655 @default.
- W2007200101 hasConcept C2779134260 @default.
- W2007200101 hasConcept C2780564577 @default.
- W2007200101 hasConcept C2781232474 @default.
- W2007200101 hasConcept C47348012 @default.
- W2007200101 hasConcept C49039625 @default.
- W2007200101 hasConcept C542903549 @default.
- W2007200101 hasConcept C555293320 @default.
- W2007200101 hasConcept C71924100 @default.
- W2007200101 hasConceptScore W2007200101C126322002 @default.
- W2007200101 hasConceptScore W2007200101C134018914 @default.
- W2007200101 hasConceptScore W2007200101C156730664 @default.
- W2007200101 hasConceptScore W2007200101C159654299 @default.
- W2007200101 hasConceptScore W2007200101C163864487 @default.
- W2007200101 hasConceptScore W2007200101C170493617 @default.
- W2007200101 hasConceptScore W2007200101C17991360 @default.
- W2007200101 hasConceptScore W2007200101C203014093 @default.
- W2007200101 hasConceptScore W2007200101C2777138892 @default.
- W2007200101 hasConceptScore W2007200101C2777180221 @default.