FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007200276> ?p ?o ?g. }

• W2007200276 endingPage "597" @default.
• W2007200276 startingPage "589" @default.
• W2007200276 abstract "Proteins p130 and E2f4, members of the retinoblastoma protein (pRb) family/E2F transcription factor family, are the key elements in regulation of cell cycle and differentiation. The functional role of the p130/E2f4 in mesenchymal stem cells (MSC) is unclear. We demonstrate here that activation of the Wnt/β-catenin pathway in mouse MSC is associated with accumulation of active forms of the p130, E2f4, and β-catenin but does not result in inhibition of cell cycle progression. The levels and phosphorylation patterns of p130, E2f4, and β-catenin in MSC do not change during cell cycle progression. This is different from control T98G glyoblastoma cells that accumulated differently phosphorylated forms of the p130 in quiescence, and under active proliferation. In MSC, synchronized at G0/G1 and S cell cycle phases, the p130 and β-catenin physically interact each other, whereas Gsk3β was associated and co-precipitated with both p130 and β-catenin. Our results indicate that Wnt/β-catenin and pRb signal pathways interact with each other and form common p130/Gsk3β/β-catenin complex during MSC cycle progression. Physiological relevance of such complex may be associated with coupling of the cell cycle and differentiation in MSC, which is related to a wide differentiation potential of these stem cells." @default.
• W2007200276 created "2016-06-24" @default.
• W2007200276 creator A5015342075 @default.
• W2007200276 creator A5047151903 @default.
• W2007200276 creator A5052676413 @default.
• W2007200276 creator A5061551264 @default.
• W2007200276 creator A5083105473 @default.
• W2007200276 date "2012-03-01" @default.
• W2007200276 modified "2023-09-26" @default.
• W2007200276 title "Induction of Wnt/β-Catenin Signaling in Mouse Mesenchymal Stem Cells Is Associated with Activation of the p130 and E2f4 and Formation of the p130/Gsk3β/β-Catenin Complex" @default.
• W2007200276 cites W1265915885 @default.
• W2007200276 cites W1554815317 @default.
• W2007200276 cites W1896727857 @default.
• W2007200276 cites W1971034699 @default.
• W2007200276 cites W1979256988 @default.
• W2007200276 cites W1979993283 @default.
• W2007200276 cites W1997237361 @default.
• W2007200276 cites W1999330214 @default.
• W2007200276 cites W2010025781 @default.
• W2007200276 cites W201567762 @default.
• W2007200276 cites W2021299555 @default.
• W2007200276 cites W2024293597 @default.
• W2007200276 cites W2065906581 @default.
• W2007200276 cites W2071427066 @default.
• W2007200276 cites W2073960683 @default.
• W2007200276 cites W2082001657 @default.
• W2007200276 cites W2087124418 @default.
• W2007200276 cites W2093686085 @default.
• W2007200276 cites W2097946485 @default.
• W2007200276 cites W2100861348 @default.
• W2007200276 cites W2103632622 @default.
• W2007200276 cites W2132786809 @default.
• W2007200276 cites W2135220644 @default.
• W2007200276 cites W2155507705 @default.
• W2007200276 cites W2156397151 @default.
• W2007200276 cites W2172249054 @default.
• W2007200276 cites W2414824546 @default.
• W2007200276 doi "https://doi.org/10.1089/scd.2011.0048" @default.
• W2007200276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280596" @default.
• W2007200276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21631154" @default.
• W2007200276 hasPublicationYear "2012" @default.
• W2007200276 type Work @default.
• W2007200276 sameAs 2007200276 @default.
• W2007200276 citedByCount "13" @default.
• W2007200276 countsByYear W20072002762013 @default.
• W2007200276 countsByYear W20072002762014 @default.
• W2007200276 countsByYear W20072002762016 @default.
• W2007200276 countsByYear W20072002762018 @default.
• W2007200276 countsByYear W20072002762019 @default.
• W2007200276 countsByYear W20072002762020 @default.
• W2007200276 countsByYear W20072002762023 @default.
• W2007200276 crossrefType "journal-article" @default.
• W2007200276 hasAuthorship W2007200276A5015342075 @default.
• W2007200276 hasAuthorship W2007200276A5047151903 @default.
• W2007200276 hasAuthorship W2007200276A5052676413 @default.
• W2007200276 hasAuthorship W2007200276A5061551264 @default.
• W2007200276 hasAuthorship W2007200276A5083105473 @default.
• W2007200276 hasBestOaLocation W20072002762 @default.
• W2007200276 hasConcept C104317684 @default.
• W2007200276 hasConcept C137620995 @default.
• W2007200276 hasConcept C1491633281 @default.
• W2007200276 hasConcept C198826908 @default.
• W2007200276 hasConcept C2776062698 @default.
• W2007200276 hasConcept C2779324961 @default.
• W2007200276 hasConcept C28328180 @default.
• W2007200276 hasConcept C29537977 @default.
• W2007200276 hasConcept C30145163 @default.
• W2007200276 hasConcept C502942594 @default.
• W2007200276 hasConcept C54355233 @default.
• W2007200276 hasConcept C62478195 @default.
• W2007200276 hasConcept C83258922 @default.
• W2007200276 hasConcept C86339819 @default.
• W2007200276 hasConcept C86803240 @default.
• W2007200276 hasConcept C95444343 @default.
• W2007200276 hasConceptScore W2007200276C104317684 @default.
• W2007200276 hasConceptScore W2007200276C137620995 @default.
• W2007200276 hasConceptScore W2007200276C1491633281 @default.
• W2007200276 hasConceptScore W2007200276C198826908 @default.
• W2007200276 hasConceptScore W2007200276C2776062698 @default.
• W2007200276 hasConceptScore W2007200276C2779324961 @default.
• W2007200276 hasConceptScore W2007200276C28328180 @default.
• W2007200276 hasConceptScore W2007200276C29537977 @default.
• W2007200276 hasConceptScore W2007200276C30145163 @default.
• W2007200276 hasConceptScore W2007200276C502942594 @default.
• W2007200276 hasConceptScore W2007200276C54355233 @default.
• W2007200276 hasConceptScore W2007200276C62478195 @default.
• W2007200276 hasConceptScore W2007200276C83258922 @default.
• W2007200276 hasConceptScore W2007200276C86339819 @default.
• W2007200276 hasConceptScore W2007200276C86803240 @default.
• W2007200276 hasConceptScore W2007200276C95444343 @default.
• W2007200276 hasIssue "4" @default.
• W2007200276 hasLocation W20072002761 @default.
• W2007200276 hasLocation W20072002762 @default.
• W2007200276 hasLocation W20072002763 @default.
• W2007200276 hasLocation W20072002764 @default.
• W2007200276 hasOpenAccess W2007200276 @default.
• W2007200276 hasPrimaryLocation W20072002761 @default.
• W2007200276 hasRelatedWork W1481014355 @default.

• next