Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007201178> ?p ?o ?g. }
- W2007201178 endingPage "234" @default.
- W2007201178 startingPage "221" @default.
- W2007201178 abstract "In demyelinating diseases, such as multiple sclerosis, an upregulation of MHC class I expression is thought to contribute to oligodendrocyte/myelin damage. In order to investigate potential physiological consequences of upregulated MHC class I expression in oligodendrocytes, we generated transgenic mice that overexpress H-2L(d) under the control of the proteolipid protein (PLP) promoter (PLP-L(d) mice). We focused our studies on the MHC class I molecule H-2L(d), because of its unique intracellular transport characteristics. In the CNS of PLP-L(d) mice, H-2L(d) was expressed by oligodendrocytes. Furthermore, H-2L(d) protein was transported to and expressed on the surface of oligodendrocytes. Most importantly, this upregulation of MHC class I expression in the CNS of PLP-L(d) mice did not by itself result in a de- or dysmyelinating phenotype. These transgenic mice are likely to provide a unique and novel tool for the analysis of potential roles of MHC class I-mediated mechanisms in demyelinating pathologies." @default.
- W2007201178 created "2016-06-24" @default.
- W2007201178 creator A5015662062 @default.
- W2007201178 creator A5025939467 @default.
- W2007201178 creator A5032202964 @default.
- W2007201178 creator A5062518246 @default.
- W2007201178 date "2001-08-01" @default.
- W2007201178 modified "2023-09-24" @default.
- W2007201178 title "Normal CNS Myelination in Transgenic Mice Overexpressing MHC Class I H-2Ld in Oligodendrocytes" @default.
- W2007201178 cites W1490503786 @default.
- W2007201178 cites W1495075491 @default.
- W2007201178 cites W1497278722 @default.
- W2007201178 cites W1523366328 @default.
- W2007201178 cites W1574058259 @default.
- W2007201178 cites W1582795450 @default.
- W2007201178 cites W1646593409 @default.
- W2007201178 cites W1746654597 @default.
- W2007201178 cites W1851819680 @default.
- W2007201178 cites W1954866769 @default.
- W2007201178 cites W1967613105 @default.
- W2007201178 cites W1976180595 @default.
- W2007201178 cites W1987078182 @default.
- W2007201178 cites W1990894161 @default.
- W2007201178 cites W1992586348 @default.
- W2007201178 cites W1994789378 @default.
- W2007201178 cites W1995518714 @default.
- W2007201178 cites W1997409891 @default.
- W2007201178 cites W1999097527 @default.
- W2007201178 cites W2001062595 @default.
- W2007201178 cites W2003803320 @default.
- W2007201178 cites W2014266629 @default.
- W2007201178 cites W2018233879 @default.
- W2007201178 cites W2019939273 @default.
- W2007201178 cites W2022229085 @default.
- W2007201178 cites W2026615583 @default.
- W2007201178 cites W2027557576 @default.
- W2007201178 cites W2030213337 @default.
- W2007201178 cites W2035199397 @default.
- W2007201178 cites W2040008103 @default.
- W2007201178 cites W2044140027 @default.
- W2007201178 cites W2046313016 @default.
- W2007201178 cites W2049267467 @default.
- W2007201178 cites W2049914560 @default.
- W2007201178 cites W2057656150 @default.
- W2007201178 cites W2059994807 @default.
- W2007201178 cites W2064864270 @default.
- W2007201178 cites W2068206249 @default.
- W2007201178 cites W2071901140 @default.
- W2007201178 cites W2072589738 @default.
- W2007201178 cites W2074270840 @default.
- W2007201178 cites W2076539151 @default.
- W2007201178 cites W2077454177 @default.
- W2007201178 cites W2078827912 @default.
- W2007201178 cites W2080595384 @default.
- W2007201178 cites W2082496572 @default.
- W2007201178 cites W2084147966 @default.
- W2007201178 cites W2088359090 @default.
- W2007201178 cites W2098589841 @default.
- W2007201178 cites W2101108802 @default.
- W2007201178 cites W2112064552 @default.
- W2007201178 cites W2116379750 @default.
- W2007201178 cites W2129649868 @default.
- W2007201178 cites W2134765811 @default.
- W2007201178 cites W2148443138 @default.
- W2007201178 cites W2150181574 @default.
- W2007201178 cites W2155789219 @default.
- W2007201178 cites W2157274298 @default.
- W2007201178 cites W2170335529 @default.
- W2007201178 cites W2400548961 @default.
- W2007201178 cites W2767648819 @default.
- W2007201178 cites W4231064823 @default.
- W2007201178 cites W4256319407 @default.
- W2007201178 cites W4294216491 @default.
- W2007201178 doi "https://doi.org/10.1006/mcne.2001.1011" @default.
- W2007201178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11520182" @default.
- W2007201178 hasPublicationYear "2001" @default.
- W2007201178 type Work @default.
- W2007201178 sameAs 2007201178 @default.
- W2007201178 citedByCount "28" @default.
- W2007201178 countsByYear W20072011782013 @default.
- W2007201178 countsByYear W20072011782014 @default.
- W2007201178 countsByYear W20072011782018 @default.
- W2007201178 countsByYear W20072011782020 @default.
- W2007201178 countsByYear W20072011782021 @default.
- W2007201178 crossrefType "journal-article" @default.
- W2007201178 hasAuthorship W2007201178A5015662062 @default.
- W2007201178 hasAuthorship W2007201178A5025939467 @default.
- W2007201178 hasAuthorship W2007201178A5032202964 @default.
- W2007201178 hasAuthorship W2007201178A5062518246 @default.
- W2007201178 hasConcept C102230213 @default.
- W2007201178 hasConcept C104317684 @default.
- W2007201178 hasConcept C127561419 @default.
- W2007201178 hasConcept C141035611 @default.
- W2007201178 hasConcept C147483822 @default.
- W2007201178 hasConcept C169760540 @default.
- W2007201178 hasConcept C170627219 @default.
- W2007201178 hasConcept C203014093 @default.
- W2007201178 hasConcept C207936829 @default.