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- W2007201321 abstract "O-9 Introduction: Hypoperfusion of splanchnic organs during haemorrhagic shock may lead to sepsis and multiple organ failure. Little is known about dynamic flow distribution within the splanchnic region in circulatory shock. Recently a multichannel laser Doppler flowmeter system (LDF) has become available that can measure microcirculatory flow (MBF) in multiple organs simultaneously and continuously. Objectives: The aim of this study was to compare systemic (cardiac index; CI), regional (superior mesenteric artery flow; SMA flow), and local flow (MBF) in multiple abdominal organs during haemorrhagic shock in anaesthetized pigs. Methods: Seven pigs (25 kg), anaesthetized with 0.6% halothane, N2O:O2(2:1), fentanyl and pancuronium, were bled to a MAP of 40 mmHg. After 180 min the shed blood was retransfused. MBF was measured in the intestinal mucosa (stomach, jejunum, colon), pancreas, liver and kidney by LDF, and SMA flow by ultrasonic transit time flowmetry. Data are presented as mean percentages of baseline. Results: During shock, MBF decreased by 15-30% in the stomach and colon mucosa, similar to the SMA flow, while the jejunal flow remained virtually unchanged. Flow in the liver and kidney decreased somewhat more (30-40%), but flow in the pancreas was most severely affected and decreased by 60%. After retransfusion of shed blood, SMA flow increased to 30% above baseline. Although microcirculatory flow in the pancreas increased slightly after retransfusion it remained 20% below baseline. Conclusion: 1. MBF in the intestinal mucosa of the stomach and colon decreased similarly to the SMA flow during shock and recovered promptly after retransfusion of shed blood. 2. In contrast, MBF in the jejunal mucosa did not decrease during shock, suggesting an intact autoregulation. 3. The pancreas appears to be particularly vulnerable to haemorrhage, since MBF decreased significantly more than CI and SMA flow." @default.
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- W2007201321 date "1998-11-01" @default.
- W2007201321 modified "2023-09-25" @default.
- W2007201321 title "Heterogeneous distribution of microcirculatory flow in the gastrointestinal tract during haemorrhage in anaesthetized pigs" @default.
- W2007201321 doi "https://doi.org/10.1097/00003643-199811000-00038" @default.
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