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- W2007201330 endingPage "70" @default.
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- W2007201330 abstract "β-Catenin is the key transcriptional activator of canonical Wnt signaling in the nucleus; thus, nuclear accumulation of β-catenin is a critical step for expressing target genes. β-Catenin accumulates in the nucleus of cancer cells where it activates oncogenic target genes. Hu antigen R (HuR) is a RNA binding protein that regulates multiple post-transcriptional processes including RNA stability. Thus, cytoplasmic HuR protein may be involved in tumorigenesis by stabilizing oncogenic transcripts, but the molecular mechanism remains unclear. Here, we observed that Wnt/β-catenin signaling induced export of the HuR protein, whereas HuR overexpression promoted accumulation of the β-catenin protein in the cytoplasm. Thus, Wnt/β-catenin-mediated transcriptional activity in the nucleus was reduced by overexpressing HuR. These results suggest novel and uncharacterized cytoplasmic β-catenin functions related to HuR-mediated RNA metabolism in cancer cells." @default.
- W2007201330 created "2016-06-24" @default.
- W2007201330 creator A5062812749 @default.
- W2007201330 creator A5068376728 @default.
- W2007201330 creator A5074283750 @default.
- W2007201330 date "2015-01-01" @default.
- W2007201330 modified "2023-10-16" @default.
- W2007201330 title "HuR represses Wnt/β-catenin-mediated transcriptional activity by promoting cytoplasmic localization of β-catenin" @default.
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- W2007201330 doi "https://doi.org/10.1016/j.bbrc.2014.12.052" @default.
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