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• W2007202521 endingPage "1453" @default.
• W2007202521 startingPage "1446" @default.
• W2007202521 abstract "Aquaporin 1 (AQP1) is a plasma membrane water-transporting protein expressed strongly in tumor microvascular endothelia. We previously reported impaired angiogenesis in implanted tumors in AQP1-deficient mice and reduced migration of AQP1-deficient endothelial cells in vitro. Here, we investigated the consequences of AQP1 deficiency in mice that spontaneously develop well-differentiated, luminal-type breast adenomas with lung metastases [mouse mammary tumor virus-driven polyoma virus middle T oncogene (MMTV-PyVT)]. AQP1+/+ MMTV-PyVT mice developed large breast tumors with total tumor mass 3.5 ± 0.5 g and volume 265 ± 36 mm3 (se, 11 mice) at age 98 d. Tumor mass (1.6±0.2 g) and volume (131±15 mm3, 12 mice) were greatly reduced in AQP1–/– MMTV-PyVT mice (P<0.005). CD31 immunofluorescence showed abnormal microvascular anatomy in tumors of AQP1–/– MMTV-PyVT mice, with reduced vessel density. HIF-1α expression was increased in tumors in AQP1–/– MMTV-PyVT mice. The number of lung metastases (5± 1/mouse) was much lower than in AQP1+/+ MMTV-PyVT mice (31±8/mouse, P<0.005). These results implicate AQP1 as an important determinant of tumor angiogenesis and, hence, as a potential drug target for adjuvant therapy of solid tumors.—Esteva-Font, C., Jin, B.-J., Verkman, A. S. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB J. 28, 1446–1453 (2014). www.fasebj.org" @default.
• W2007202521 created "2016-06-24" @default.
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• W2007202521 date "2013-12-12" @default.
• W2007202521 modified "2023-10-15" @default.
• W2007202521 title "Aquaporin‐1 gene deletion reduces breast tumor growth and lung metastasis in tumor‐producing MMTV‐PyVT mice" @default.
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• W2007202521 doi "https://doi.org/10.1096/fj.13-245621" @default.
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