Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007203304> ?p ?o ?g. }
- W2007203304 endingPage "223" @default.
- W2007203304 startingPage "217" @default.
- W2007203304 abstract "Although pulmonary infections caused by Pseudomonas aeruginosa can hardly be eradicated in patients with cystic fibrosis (CF, the most common genetic disease among Caucasians), these patients are mainly treated with intravenous and nebulized tobramycin. Long-term treatment with tobramycin, however, may induce ototoxic effects. We assessed the clinical histories and postmortem temporal bones of six patients with CF for signs of this ototoxicity. Four bones showed typical manifestations of ototoxicity induced by aminoglycosides (AGs): loss of hair cells in the lower turns, and degeneration of ganglion cells. Six bones revealed no loss or scattered loss of hair cells, however, degeneration of the spiral ganglion cells was observed. This suggests that degeneration of the spiral ganglion may occur as a primary manifestation in some cases of ototoxicity due to aminoglycosides. Recent reports have shown that trophic factors (neurotrophins and acidic fibroblast growth factor) interacting with hair cells and the spiral ganglion protect the inner ear from damage. It may be that disturbances in supply of such trophic factors caused degeneration of ganglion cells without loss of hair cells in the cases we studied." @default.
- W2007203304 created "2016-06-24" @default.
- W2007203304 creator A5033649799 @default.
- W2007203304 creator A5045992163 @default.
- W2007203304 creator A5064787486 @default.
- W2007203304 date "1998-01-01" @default.
- W2007203304 modified "2023-10-10" @default.
- W2007203304 title "Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity" @default.
- W2007203304 cites W1560997416 @default.
- W2007203304 cites W1572697206 @default.
- W2007203304 cites W171916006 @default.
- W2007203304 cites W1808995917 @default.
- W2007203304 cites W1964478912 @default.
- W2007203304 cites W1970288210 @default.
- W2007203304 cites W1978761075 @default.
- W2007203304 cites W1979030189 @default.
- W2007203304 cites W1983314786 @default.
- W2007203304 cites W1987777249 @default.
- W2007203304 cites W1992964587 @default.
- W2007203304 cites W1998043801 @default.
- W2007203304 cites W1999260607 @default.
- W2007203304 cites W2005463933 @default.
- W2007203304 cites W2006018333 @default.
- W2007203304 cites W2011532151 @default.
- W2007203304 cites W2011951794 @default.
- W2007203304 cites W2024204256 @default.
- W2007203304 cites W2025449195 @default.
- W2007203304 cites W2030631267 @default.
- W2007203304 cites W2033379900 @default.
- W2007203304 cites W2036001251 @default.
- W2007203304 cites W2042602489 @default.
- W2007203304 cites W2045050168 @default.
- W2007203304 cites W2058359348 @default.
- W2007203304 cites W2068459848 @default.
- W2007203304 cites W2072780171 @default.
- W2007203304 cites W2078114493 @default.
- W2007203304 cites W2094449231 @default.
- W2007203304 cites W2101414734 @default.
- W2007203304 cites W2101808060 @default.
- W2007203304 cites W2128552228 @default.
- W2007203304 cites W2138295890 @default.
- W2007203304 cites W2154177544 @default.
- W2007203304 cites W2162598892 @default.
- W2007203304 cites W2287857657 @default.
- W2007203304 cites W2326284878 @default.
- W2007203304 cites W2326546510 @default.
- W2007203304 cites W2400520874 @default.
- W2007203304 cites W2416026395 @default.
- W2007203304 cites W2471401049 @default.
- W2007203304 cites W4211178971 @default.
- W2007203304 doi "https://doi.org/10.1016/s0378-5955(97)00191-3" @default.
- W2007203304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9472750" @default.
- W2007203304 hasPublicationYear "1998" @default.
- W2007203304 type Work @default.
- W2007203304 sameAs 2007203304 @default.
- W2007203304 citedByCount "62" @default.
- W2007203304 countsByYear W20072033042012 @default.
- W2007203304 countsByYear W20072033042013 @default.
- W2007203304 countsByYear W20072033042014 @default.
- W2007203304 countsByYear W20072033042015 @default.
- W2007203304 countsByYear W20072033042017 @default.
- W2007203304 countsByYear W20072033042018 @default.
- W2007203304 countsByYear W20072033042019 @default.
- W2007203304 countsByYear W20072033042020 @default.
- W2007203304 countsByYear W20072033042021 @default.
- W2007203304 countsByYear W20072033042023 @default.
- W2007203304 crossrefType "journal-article" @default.
- W2007203304 hasAuthorship W2007203304A5033649799 @default.
- W2007203304 hasAuthorship W2007203304A5045992163 @default.
- W2007203304 hasAuthorship W2007203304A5064787486 @default.
- W2007203304 hasConcept C105702510 @default.
- W2007203304 hasConcept C126322002 @default.
- W2007203304 hasConcept C142724271 @default.
- W2007203304 hasConcept C162903589 @default.
- W2007203304 hasConcept C2775832221 @default.
- W2007203304 hasConcept C2776694085 @default.
- W2007203304 hasConcept C2777787772 @default.
- W2007203304 hasConcept C2778239845 @default.
- W2007203304 hasConcept C2778500370 @default.
- W2007203304 hasConcept C2778534666 @default.
- W2007203304 hasConcept C2778585322 @default.
- W2007203304 hasConcept C2778974779 @default.
- W2007203304 hasConcept C2779152698 @default.
- W2007203304 hasConcept C2779354088 @default.
- W2007203304 hasConcept C2780493683 @default.
- W2007203304 hasConcept C2780757810 @default.
- W2007203304 hasConcept C2781334511 @default.
- W2007203304 hasConcept C501593827 @default.
- W2007203304 hasConcept C54355233 @default.
- W2007203304 hasConcept C548259974 @default.
- W2007203304 hasConcept C71924100 @default.
- W2007203304 hasConcept C86803240 @default.
- W2007203304 hasConceptScore W2007203304C105702510 @default.
- W2007203304 hasConceptScore W2007203304C126322002 @default.
- W2007203304 hasConceptScore W2007203304C142724271 @default.
- W2007203304 hasConceptScore W2007203304C162903589 @default.
- W2007203304 hasConceptScore W2007203304C2775832221 @default.
- W2007203304 hasConceptScore W2007203304C2776694085 @default.