FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007203367> ?p ?o ?g. }

• W2007203367 endingPage "94" @default.
• W2007203367 startingPage "87" @default.
• W2007203367 abstract "High serum levels of vascular endothelial growth factor (VEGF) are a poor prognostic factor for patients with advanced non-small-cell lung cancer (NSCLC). We have previously shown that low-dose interleukin (IL)-2 and 13-cis retinoic acid (RA) decreased VEGF and improved the immune function of patients with advanced tumors treated with chemotherapy. The primary end point of this study was to verify whether IL-2 and RA decreased serum VEGF in NSCLC patients showing a clinical benefit from chemotherapy. The secondary end point was the evaluation of clinical outcome. We treated 38 patients with advanced NSCLC who had a complete or partial response or disease stability to chemotherapy and had a median serum VEGF level of 508 ng/mL; as maintenance therapy, they received subcutaneous IL-2 (1.8 × 106 IU) and oral RA. Matched controls (n = 87) were selected from a large cohort of patients with a similar disease status, including clinical benefit from chemotherapy. The most common adverse events were mild cutaneous skin rash and fever. Serum VEGF decreased to a mean level of 152 ng/mL (P = 0.0002). A statistically significant improvement in immune function was observed (lymphocyte and natural killer cell numbers and CD4+/CD8+ ratio) with respect to baseline values and controls. An improvement in the clinical outcome was also observed compared with controls. These data show that the administration of low-dose subcutaneous IL-2 and oral RA to patients with advanced NSCLC showing a clinical benefit from chemotherapy is feasible with a low-toxicity profile, decreases VEGF, and seems to improve progression-free and overall survival." @default.
• W2007203367 created "2016-06-24" @default.
• W2007203367 creator A5005431384 @default.
• W2007203367 creator A5005705216 @default.
• W2007203367 creator A5027002636 @default.
• W2007203367 creator A5041662900 @default.
• W2007203367 creator A5042153748 @default.
• W2007203367 creator A5047522068 @default.
• W2007203367 creator A5063573604 @default.
• W2007203367 creator A5074263826 @default.
• W2007203367 creator A5074746794 @default.
• W2007203367 date "2006-01-01" @default.
• W2007203367 modified "2023-10-03" @default.
• W2007203367 title "Multicenter Phase 2 Study of Interleukin-2 and 13-Cis Retinoic Acid as Maintenance Therapy in Advanced Non-Small-Cell Lung Cancer" @default.
• W2007203367 cites W1972845462 @default.
• W2007203367 cites W1983273033 @default.
• W2007203367 cites W1996654617 @default.
• W2007203367 cites W2017352677 @default.
• W2007203367 cites W2022256357 @default.
• W2007203367 cites W2026263341 @default.
• W2007203367 cites W2030192997 @default.
• W2007203367 cites W2033159661 @default.
• W2007203367 cites W2039883833 @default.
• W2007203367 cites W2052984045 @default.
• W2007203367 cites W2061825778 @default.
• W2007203367 cites W2076968769 @default.
• W2007203367 cites W2105283525 @default.
• W2007203367 cites W2113257521 @default.
• W2007203367 cites W2123914905 @default.
• W2007203367 cites W2124606152 @default.
• W2007203367 cites W2139248078 @default.
• W2007203367 cites W2150358925 @default.
• W2007203367 cites W2153804947 @default.
• W2007203367 cites W2169997396 @default.
• W2007203367 cites W2319983832 @default.
• W2007203367 cites W2616141209 @default.
• W2007203367 cites W4239714259 @default.
• W2007203367 cites W4248626267 @default.
• W2007203367 cites W4250643419 @default.
• W2007203367 cites W4293241248 @default.
• W2007203367 doi "https://doi.org/10.1097/01.cji.0000186244.85058.1b" @default.
• W2007203367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16365604" @default.
• W2007203367 hasPublicationYear "2006" @default.
• W2007203367 type Work @default.
• W2007203367 sameAs 2007203367 @default.
• W2007203367 citedByCount "27" @default.
• W2007203367 countsByYear W20072033672012 @default.
• W2007203367 countsByYear W20072033672013 @default.
• W2007203367 countsByYear W20072033672014 @default.
• W2007203367 countsByYear W20072033672016 @default.
• W2007203367 countsByYear W20072033672018 @default.
• W2007203367 countsByYear W20072033672019 @default.
• W2007203367 countsByYear W20072033672020 @default.
• W2007203367 countsByYear W20072033672021 @default.
• W2007203367 countsByYear W20072033672022 @default.
• W2007203367 crossrefType "journal-article" @default.
• W2007203367 hasAuthorship W2007203367A5005431384 @default.
• W2007203367 hasAuthorship W2007203367A5005705216 @default.
• W2007203367 hasAuthorship W2007203367A5027002636 @default.
• W2007203367 hasAuthorship W2007203367A5041662900 @default.
• W2007203367 hasAuthorship W2007203367A5042153748 @default.
• W2007203367 hasAuthorship W2007203367A5047522068 @default.
• W2007203367 hasAuthorship W2007203367A5063573604 @default.
• W2007203367 hasAuthorship W2007203367A5074263826 @default.
• W2007203367 hasAuthorship W2007203367A5074746794 @default.
• W2007203367 hasConcept C126322002 @default.
• W2007203367 hasConcept C143998085 @default.
• W2007203367 hasConcept C167734588 @default.
• W2007203367 hasConcept C197934379 @default.
• W2007203367 hasConcept C203092338 @default.
• W2007203367 hasConcept C2776256026 @default.
• W2007203367 hasConcept C2776694085 @default.
• W2007203367 hasConcept C2776907518 @default.
• W2007203367 hasConcept C2777025900 @default.
• W2007203367 hasConcept C2778283404 @default.
• W2007203367 hasConcept C2778570526 @default.
• W2007203367 hasConcept C2778822529 @default.
• W2007203367 hasConcept C535046627 @default.
• W2007203367 hasConcept C71924100 @default.
• W2007203367 hasConcept C90924648 @default.
• W2007203367 hasConceptScore W2007203367C126322002 @default.
• W2007203367 hasConceptScore W2007203367C143998085 @default.
• W2007203367 hasConceptScore W2007203367C167734588 @default.
• W2007203367 hasConceptScore W2007203367C197934379 @default.
• W2007203367 hasConceptScore W2007203367C203092338 @default.
• W2007203367 hasConceptScore W2007203367C2776256026 @default.
• W2007203367 hasConceptScore W2007203367C2776694085 @default.
• W2007203367 hasConceptScore W2007203367C2776907518 @default.
• W2007203367 hasConceptScore W2007203367C2777025900 @default.
• W2007203367 hasConceptScore W2007203367C2778283404 @default.
• W2007203367 hasConceptScore W2007203367C2778570526 @default.
• W2007203367 hasConceptScore W2007203367C2778822529 @default.
• W2007203367 hasConceptScore W2007203367C535046627 @default.
• W2007203367 hasConceptScore W2007203367C71924100 @default.
• W2007203367 hasConceptScore W2007203367C90924648 @default.
• W2007203367 hasIssue "1" @default.
• W2007203367 hasLocation W20072033671 @default.
• W2007203367 hasLocation W20072033672 @default.

• next