Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007203481> ?p ?o ?g. }
- W2007203481 endingPage "120" @default.
- W2007203481 startingPage "113" @default.
- W2007203481 abstract "Angiogenesis is the process of new blood vessel formation from pre-existing ones. Angiogenic factors contribute to neovascularization that takes place in angiogenesis-dependent diseases, including cancer. Inhibiting the activity of the angiogenic factors to block the angiogenesis pathways is the current strategy of cancer therapy. Basic fibroblast growth factor (bFGF) is regarded as one of the most important angiogenic factors. Herein, we selected polyoxometalates (POMs) with different structures to study the interactions between bFGF and POMs. The results show that POMs could bind to the protein with high affinity, causing detectable changes in conformation and biophysical properties of protein. In addition, POMs could effectively inhibit the cell proliferation induced by bFGF. Significantly, we found that the structure, size and composition of POMs play a key role in the interactions between bFGF and POMs. This study will be meaningful for future screening and design of polyoxometalate-based anticancer drugs." @default.
- W2007203481 created "2016-06-24" @default.
- W2007203481 creator A5024214452 @default.
- W2007203481 creator A5029988151 @default.
- W2007203481 creator A5065069789 @default.
- W2007203481 creator A5079873312 @default.
- W2007203481 date "2013-01-01" @default.
- W2007203481 modified "2023-10-18" @default.
- W2007203481 title "Identification of polyoxometalates as inhibitors of basic fibroblast growth factor" @default.
- W2007203481 cites W1501818109 @default.
- W2007203481 cites W1579703324 @default.
- W2007203481 cites W174617300 @default.
- W2007203481 cites W1868679695 @default.
- W2007203481 cites W1891705969 @default.
- W2007203481 cites W19332709 @default.
- W2007203481 cites W1957742134 @default.
- W2007203481 cites W1965144118 @default.
- W2007203481 cites W1971828920 @default.
- W2007203481 cites W1972708655 @default.
- W2007203481 cites W1975746667 @default.
- W2007203481 cites W1980822767 @default.
- W2007203481 cites W1984383995 @default.
- W2007203481 cites W1986309234 @default.
- W2007203481 cites W1989392905 @default.
- W2007203481 cites W1989468344 @default.
- W2007203481 cites W1990327096 @default.
- W2007203481 cites W1995648328 @default.
- W2007203481 cites W1999873283 @default.
- W2007203481 cites W2004612743 @default.
- W2007203481 cites W2008630616 @default.
- W2007203481 cites W2015817132 @default.
- W2007203481 cites W2025074879 @default.
- W2007203481 cites W2028545463 @default.
- W2007203481 cites W2034379846 @default.
- W2007203481 cites W2035733019 @default.
- W2007203481 cites W2048188367 @default.
- W2007203481 cites W2051343837 @default.
- W2007203481 cites W2057559166 @default.
- W2007203481 cites W2058239412 @default.
- W2007203481 cites W2066196983 @default.
- W2007203481 cites W2068748585 @default.
- W2007203481 cites W2070671834 @default.
- W2007203481 cites W2085904053 @default.
- W2007203481 cites W2086219501 @default.
- W2007203481 cites W2087235278 @default.
- W2007203481 cites W2110550680 @default.
- W2007203481 cites W2122892477 @default.
- W2007203481 cites W2124328673 @default.
- W2007203481 cites W2125332806 @default.
- W2007203481 cites W2125475888 @default.
- W2007203481 cites W2144026946 @default.
- W2007203481 cites W2157991142 @default.
- W2007203481 cites W2168666668 @default.
- W2007203481 cites W2203718906 @default.
- W2007203481 cites W2274167915 @default.
- W2007203481 cites W2284037161 @default.
- W2007203481 cites W2321997840 @default.
- W2007203481 cites W2403815535 @default.
- W2007203481 cites W2465252050 @default.
- W2007203481 cites W4255042798 @default.
- W2007203481 doi "https://doi.org/10.1039/c2mb25389e" @default.
- W2007203481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23123725" @default.
- W2007203481 hasPublicationYear "2013" @default.
- W2007203481 type Work @default.
- W2007203481 sameAs 2007203481 @default.
- W2007203481 citedByCount "23" @default.
- W2007203481 countsByYear W20072034812014 @default.
- W2007203481 countsByYear W20072034812015 @default.
- W2007203481 countsByYear W20072034812016 @default.
- W2007203481 countsByYear W20072034812017 @default.
- W2007203481 countsByYear W20072034812018 @default.
- W2007203481 countsByYear W20072034812019 @default.
- W2007203481 countsByYear W20072034812020 @default.
- W2007203481 countsByYear W20072034812021 @default.
- W2007203481 countsByYear W20072034812022 @default.
- W2007203481 crossrefType "journal-article" @default.
- W2007203481 hasAuthorship W2007203481A5024214452 @default.
- W2007203481 hasAuthorship W2007203481A5029988151 @default.
- W2007203481 hasAuthorship W2007203481A5065069789 @default.
- W2007203481 hasAuthorship W2007203481A5079873312 @default.
- W2007203481 hasConcept C161790260 @default.
- W2007203481 hasConcept C170493617 @default.
- W2007203481 hasConcept C185592680 @default.
- W2007203481 hasConcept C2775960820 @default.
- W2007203481 hasConcept C2777498215 @default.
- W2007203481 hasConcept C2777587049 @default.
- W2007203481 hasConcept C2778271429 @default.
- W2007203481 hasConcept C2780394083 @default.
- W2007203481 hasConcept C502942594 @default.
- W2007203481 hasConcept C55493867 @default.
- W2007203481 hasConcept C71924100 @default.
- W2007203481 hasConcept C74373430 @default.
- W2007203481 hasConcept C86803240 @default.
- W2007203481 hasConcept C95444343 @default.
- W2007203481 hasConceptScore W2007203481C161790260 @default.
- W2007203481 hasConceptScore W2007203481C170493617 @default.
- W2007203481 hasConceptScore W2007203481C185592680 @default.
- W2007203481 hasConceptScore W2007203481C2775960820 @default.