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• W2007205931 endingPage "160" @default.
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• W2007205931 abstract "The aim of the present study was to investigate the protective effect of compound N-[2-(4-hydroxy-phenyl)-ethyl]-2-(2,5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide (compound FLZ), a novel synthetic analogue of nature squamosamide, on Abeta25-35-induced toxicity and its active mechanism in human neuroblastoma SH-SY5Y cells.SH-SY5Y cells were pre-incubated with various concentrations of compound FLZ for 30 min and then cultivated with Abeta25-35 (25 micromol/L) for 48 h to induce neurotoxicity. Cell viability, lactate dehydrogenase (LDH) release, and the glutathione (GSH) level were determined by a biochemical analysis. The cell apoptotic ratio and intracellular reactive oxygen species (ROS) level were measured by a flow cytometry analysis. The expression of apoptosis protein (Bcl-2 and Bax) and cytochrome c release were assayed by the Western blot method.The pretreatment of SH-SY5Y cells with FLZ (1 and 10 micromol/L) markedly increased cell viability and decreased LDH release and morphological injury. Also, FLZ attenuated the Abeta25-35-induced apoptotic cell ratio, regulated the apoptosis protein (Bcl-2 and Bax) expression, and decreased the cytochrome c release from mitochondria. FLZ also significantly inhibited the generation of ROS and the depletion of GSH induced by Abeta25-35 in SH-SY5Y cells.FLZ has protective action against Abeta25-35-induced toxicity in SH-SY5Y cells, which might be mediated through its antioxidant property." @default.
• W2007205931 created "2016-06-24" @default.
• W2007205931 creator A5043490198 @default.
• W2007205931 creator A5082023146 @default.
• W2007205931 date "2008-02-01" @default.
• W2007205931 modified "2023-10-06" @default.
• W2007205931 title "Novel squamosamide derivative (compound FLZ) attenuates Aβ_25–35-induced toxicity in SH-SY5Y cells" @default.
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• W2007205931 doi "https://doi.org/10.1111/j.1745-7254.2008.00714.x" @default.
• W2007205931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18215343" @default.
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