Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007210021> ?p ?o ?g. }
- W2007210021 endingPage "11726" @default.
- W2007210021 startingPage "11721" @default.
- W2007210021 abstract "Significance In normal cells, quiescent nuclear factor κB (NFκB) is activated by inflammatory stimuli. In most cancers, the abnormal constitutive activation of NFκB contributes to malignant progression and resistance to therapy. Overexpression or constitutive activation of the EGF receptor (EGFR) in many cancers contributes to their proliferation and survival. We find that the constitutive activation of NFκB in several cancer cell lines is decreased by EGFR knockdown or by the EGFR inhibitor erlotinib. We used insertional mutagenesis to find that overexpression of Son of Sevenless 1 (SOS1), a component of EGF-dependent pathways that facilitate cell growth and survival, causes erlotinib resistance and increases NFκB activation. SOS1 is required for EGF-dependent activation of NFκB but its GDP–GTP exchange activity is not, revealing a novel function for this protein." @default.
- W2007210021 created "2016-06-24" @default.
- W2007210021 creator A5035744404 @default.
- W2007210021 creator A5058391665 @default.
- W2007210021 creator A5080998429 @default.
- W2007210021 date "2014-07-28" @default.
- W2007210021 modified "2023-09-25" @default.
- W2007210021 title "EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells" @default.
- W2007210021 cites W1493105012 @default.
- W2007210021 cites W1533671266 @default.
- W2007210021 cites W1965157624 @default.
- W2007210021 cites W1968345881 @default.
- W2007210021 cites W1969334180 @default.
- W2007210021 cites W1971944335 @default.
- W2007210021 cites W1973108551 @default.
- W2007210021 cites W1985101923 @default.
- W2007210021 cites W1990674638 @default.
- W2007210021 cites W1994275338 @default.
- W2007210021 cites W1996804310 @default.
- W2007210021 cites W1999908952 @default.
- W2007210021 cites W2002937040 @default.
- W2007210021 cites W2003243708 @default.
- W2007210021 cites W2007618944 @default.
- W2007210021 cites W2016208410 @default.
- W2007210021 cites W2030432869 @default.
- W2007210021 cites W2031019010 @default.
- W2007210021 cites W2035191293 @default.
- W2007210021 cites W2041441484 @default.
- W2007210021 cites W2042073539 @default.
- W2007210021 cites W2044322173 @default.
- W2007210021 cites W2049091707 @default.
- W2007210021 cites W2049274590 @default.
- W2007210021 cites W2050237811 @default.
- W2007210021 cites W2051994734 @default.
- W2007210021 cites W2060003123 @default.
- W2007210021 cites W2064082659 @default.
- W2007210021 cites W2065188205 @default.
- W2007210021 cites W2065589361 @default.
- W2007210021 cites W2068652881 @default.
- W2007210021 cites W2087257002 @default.
- W2007210021 cites W2087872766 @default.
- W2007210021 cites W2087955215 @default.
- W2007210021 cites W2094863064 @default.
- W2007210021 cites W2096308522 @default.
- W2007210021 cites W2097152766 @default.
- W2007210021 cites W2100660197 @default.
- W2007210021 cites W2106204137 @default.
- W2007210021 cites W2109075732 @default.
- W2007210021 cites W2112739348 @default.
- W2007210021 cites W2147648931 @default.
- W2007210021 cites W2158797210 @default.
- W2007210021 cites W2166609912 @default.
- W2007210021 cites W2172015700 @default.
- W2007210021 doi "https://doi.org/10.1073/pnas.1412390111" @default.
- W2007210021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4136585" @default.
- W2007210021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25071181" @default.
- W2007210021 hasPublicationYear "2014" @default.
- W2007210021 type Work @default.
- W2007210021 sameAs 2007210021 @default.
- W2007210021 citedByCount "43" @default.
- W2007210021 countsByYear W20072100212015 @default.
- W2007210021 countsByYear W20072100212016 @default.
- W2007210021 countsByYear W20072100212017 @default.
- W2007210021 countsByYear W20072100212018 @default.
- W2007210021 countsByYear W20072100212019 @default.
- W2007210021 countsByYear W20072100212020 @default.
- W2007210021 countsByYear W20072100212021 @default.
- W2007210021 countsByYear W20072100212022 @default.
- W2007210021 crossrefType "journal-article" @default.
- W2007210021 hasAuthorship W2007210021A5035744404 @default.
- W2007210021 hasAuthorship W2007210021A5058391665 @default.
- W2007210021 hasAuthorship W2007210021A5080998429 @default.
- W2007210021 hasBestOaLocation W20072100211 @default.
- W2007210021 hasConcept C121608353 @default.
- W2007210021 hasConcept C170493617 @default.
- W2007210021 hasConcept C173396325 @default.
- W2007210021 hasConcept C2776362946 @default.
- W2007210021 hasConcept C2777730290 @default.
- W2007210021 hasConcept C2778087573 @default.
- W2007210021 hasConcept C2779438470 @default.
- W2007210021 hasConcept C502942594 @default.
- W2007210021 hasConcept C54355233 @default.
- W2007210021 hasConcept C55493867 @default.
- W2007210021 hasConcept C62478195 @default.
- W2007210021 hasConcept C81885089 @default.
- W2007210021 hasConcept C86803240 @default.
- W2007210021 hasConcept C95444343 @default.
- W2007210021 hasConcept C96232424 @default.
- W2007210021 hasConceptScore W2007210021C121608353 @default.
- W2007210021 hasConceptScore W2007210021C170493617 @default.
- W2007210021 hasConceptScore W2007210021C173396325 @default.
- W2007210021 hasConceptScore W2007210021C2776362946 @default.
- W2007210021 hasConceptScore W2007210021C2777730290 @default.
- W2007210021 hasConceptScore W2007210021C2778087573 @default.
- W2007210021 hasConceptScore W2007210021C2779438470 @default.
- W2007210021 hasConceptScore W2007210021C502942594 @default.
- W2007210021 hasConceptScore W2007210021C54355233 @default.
- W2007210021 hasConceptScore W2007210021C55493867 @default.