Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007210546> ?p ?o ?g. }
- W2007210546 endingPage "32" @default.
- W2007210546 startingPage "23" @default.
- W2007210546 abstract "The attachment organelle of the human respiratory tract pathogen Mycoplasma pneumoniae is essential for colonization of the host mucosa. Furthermore, adherence-related proteins such as the major adhesin P1 and protein P30 represent vaccine candidates. Using the chimeric recombinant protein HP14/30, which combines surface-localized and adherence-involved regions of both proteins, we developed an optimized strategy to immunize guinea pigs. The vaccination protocol includes subcutaneous prime immunization followed by presentation of the antigen directly to the respiratory mucosa by two intranasal (i.n.) administrations and combination of antigen with the mucosal adjuvant chitosan. The immunization scheme induced high, consistent and long-lasting IgA levels in respiratory tract samples (BAL, nasal and throat washing fluid) from the animals. In comparison with a preimmune serum, incubation of M. pneumoniae cells with sera from these animals reduced the mean adhesion of bacteria to HeLa cells to 6%. After i.n. infection, immunized animals showed significantly decreased numbers of M. pneumoniae-specific genome copies, especially in the upper respiratory tract, in comparison with the control group. The results demonstrated that optimized immunization with the chimeric protein HP14/30 is promising for further vaccination efforts to prevent host colonization with M. pneumoniae." @default.
- W2007210546 created "2016-06-24" @default.
- W2007210546 creator A5003619080 @default.
- W2007210546 creator A5017237724 @default.
- W2007210546 creator A5025911349 @default.
- W2007210546 creator A5030306645 @default.
- W2007210546 creator A5046052852 @default.
- W2007210546 date "2013-11-01" @default.
- W2007210546 modified "2023-10-14" @default.
- W2007210546 title "Development of protective anti-Mycoplasma pneumoniae antibodies after immunization of guinea pigs with the combination of a P1-P30 chimeric recombinant protein and chitosan" @default.
- W2007210546 cites W1542097161 @default.
- W2007210546 cites W1844606485 @default.
- W2007210546 cites W1874588135 @default.
- W2007210546 cites W1908624447 @default.
- W2007210546 cites W1964900407 @default.
- W2007210546 cites W1965327494 @default.
- W2007210546 cites W1967162465 @default.
- W2007210546 cites W1968554826 @default.
- W2007210546 cites W1971756464 @default.
- W2007210546 cites W1972191954 @default.
- W2007210546 cites W1977072597 @default.
- W2007210546 cites W1977559696 @default.
- W2007210546 cites W1979919213 @default.
- W2007210546 cites W1993198059 @default.
- W2007210546 cites W1997681303 @default.
- W2007210546 cites W2009421264 @default.
- W2007210546 cites W2017174771 @default.
- W2007210546 cites W2021978496 @default.
- W2007210546 cites W2029245091 @default.
- W2007210546 cites W2034765332 @default.
- W2007210546 cites W2034783507 @default.
- W2007210546 cites W2035451745 @default.
- W2007210546 cites W2080136345 @default.
- W2007210546 cites W2080981711 @default.
- W2007210546 cites W2084579359 @default.
- W2007210546 cites W2085510436 @default.
- W2007210546 cites W2087781281 @default.
- W2007210546 cites W2089307044 @default.
- W2007210546 cites W2095375976 @default.
- W2007210546 cites W2100204829 @default.
- W2007210546 cites W2107961805 @default.
- W2007210546 cites W2110281620 @default.
- W2007210546 cites W2116564707 @default.
- W2007210546 cites W2119087222 @default.
- W2007210546 cites W2123634400 @default.
- W2007210546 cites W2128526548 @default.
- W2007210546 cites W2131941208 @default.
- W2007210546 cites W2143559680 @default.
- W2007210546 cites W2145380311 @default.
- W2007210546 cites W2146807745 @default.
- W2007210546 cites W2153351829 @default.
- W2007210546 cites W2171605884 @default.
- W2007210546 cites W4299415901 @default.
- W2007210546 doi "https://doi.org/10.1016/j.micpath.2013.07.004" @default.
- W2007210546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23948467" @default.
- W2007210546 hasPublicationYear "2013" @default.
- W2007210546 type Work @default.
- W2007210546 sameAs 2007210546 @default.
- W2007210546 citedByCount "18" @default.
- W2007210546 countsByYear W20072105462014 @default.
- W2007210546 countsByYear W20072105462016 @default.
- W2007210546 countsByYear W20072105462018 @default.
- W2007210546 countsByYear W20072105462019 @default.
- W2007210546 countsByYear W20072105462020 @default.
- W2007210546 countsByYear W20072105462021 @default.
- W2007210546 countsByYear W20072105462022 @default.
- W2007210546 crossrefType "journal-article" @default.
- W2007210546 hasAuthorship W2007210546A5003619080 @default.
- W2007210546 hasAuthorship W2007210546A5017237724 @default.
- W2007210546 hasAuthorship W2007210546A5025911349 @default.
- W2007210546 hasAuthorship W2007210546A5030306645 @default.
- W2007210546 hasAuthorship W2007210546A5046052852 @default.
- W2007210546 hasConcept C104317684 @default.
- W2007210546 hasConcept C105702510 @default.
- W2007210546 hasConcept C126322002 @default.
- W2007210546 hasConcept C147483822 @default.
- W2007210546 hasConcept C159047783 @default.
- W2007210546 hasConcept C159654299 @default.
- W2007210546 hasConcept C179470777 @default.
- W2007210546 hasConcept C203014093 @default.
- W2007210546 hasConcept C22070199 @default.
- W2007210546 hasConcept C2777863537 @default.
- W2007210546 hasConcept C2777914695 @default.
- W2007210546 hasConcept C2779215961 @default.
- W2007210546 hasConcept C2779644171 @default.
- W2007210546 hasConcept C2780801004 @default.
- W2007210546 hasConcept C2781253189 @default.
- W2007210546 hasConcept C501593827 @default.
- W2007210546 hasConcept C534529494 @default.
- W2007210546 hasConcept C547475151 @default.
- W2007210546 hasConcept C55493867 @default.
- W2007210546 hasConcept C71924100 @default.
- W2007210546 hasConcept C86803240 @default.
- W2007210546 hasConcept C89423630 @default.
- W2007210546 hasConceptScore W2007210546C104317684 @default.
- W2007210546 hasConceptScore W2007210546C105702510 @default.
- W2007210546 hasConceptScore W2007210546C126322002 @default.
- W2007210546 hasConceptScore W2007210546C147483822 @default.