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• W2007211412 abstract "Aging is associated with an impaired ability to maintain long-term potentiation (LTP), but the underlying cause of the impairment remains unclear. To gain a better understanding of the cellular and molecular mechanisms responsible for this impairment, the synaptic transmission and plasticity were studied in the CA1 region of hippocampal slices from adult (6-8 months) and poor-memory (PM)-aged (23-24 months) rats. The one-way inhibitory avoidance learning task was used as the behavioral paradigm to screen PM-aged rats. With intracellular recordings, CA1 neurons of PM-aged rats exhibited a more hyperpolarized resting membrane potential, reduced input resistance, and increased amplitude of afterhyperpolarization and spike threshold, compared with those in adult rats. Although a reduction in the size of excitatory synaptic response was observed in PM-aged rats, no obvious differences were found between adult and PM-aged rats in the pharmacological properties of excitatory synaptic response, paired-pulse facilitation, or frequency-dependent facilitation, which was tested with trains of 10 pulses at 1, 5, and 10 Hz. Slices from the PM-aged rats displayed significantly reduced early-phase long-term potentiation (E-LTP) and late-phase LTP (L-LTP), and the entire frequency-response curve of LTP and LTD is modified to favor LTD induction. The susceptibility of time-dependent reversal of LTP by low-frequency afferent stimulation was also facilitated in PM-aged rats. Bath application of the protein phosphatase inhibitor, calyculin A, enhanced synaptic response in slices from PM-aged, but not adult, rats. In contrast, application of the cAMP-dependent protein kinase inhibitors, Rp-8-CPT-cAMPS and KT5720, induced a decrease in synaptic transmission only in slices from the adult rats. Furthermore, the selective beta-adrenergic receptor agonist, isoproterenol, and pertussis toxin-sensitive G-protein inhibitor, N-ethylmaleimide, effectively restored the deficit in E-LTP and L-LTP of PM-aged rats. These results demonstrate that age-related impairments of synaptic transmission and LTP may result from alterations in the balance of protein kinase/phosphatase activities." @default.
• W2007211412 created "2016-06-24" @default.
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• W2007211412 date "2002-01-01" @default.
• W2007211412 modified "2023-10-18" @default.
• W2007211412 title "Alterations in the balance of protein kinase and phosphatase activities and age-related impairments of synaptic transmission and long-term potentiation" @default.
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• W2007211412 cites W1536302928 @default.
• W2007211412 cites W1562466147 @default.
• W2007211412 cites W1643173510 @default.
• W2007211412 cites W1733248925 @default.
• W2007211412 cites W1886575365 @default.
• W2007211412 cites W1969736263 @default.
• W2007211412 cites W1970613790 @default.
• W2007211412 cites W1970992446 @default.
• W2007211412 cites W1972291807 @default.
• W2007211412 cites W1972384396 @default.
• W2007211412 cites W1977592396 @default.
• W2007211412 cites W1977901685 @default.
• W2007211412 cites W1980872339 @default.
• W2007211412 cites W1984251709 @default.
• W2007211412 cites W1986212704 @default.
• W2007211412 cites W1989758719 @default.
• W2007211412 cites W1992593556 @default.
• W2007211412 cites W1992949974 @default.
• W2007211412 cites W1996710971 @default.
• W2007211412 cites W1997238851 @default.
• W2007211412 cites W1999304520 @default.
• W2007211412 cites W2002927748 @default.
• W2007211412 cites W2003106844 @default.
• W2007211412 cites W2007265755 @default.
• W2007211412 cites W2008050722 @default.
• W2007211412 cites W2018662966 @default.
• W2007211412 cites W2022924617 @default.
• W2007211412 cites W2025649764 @default.
• W2007211412 cites W2026003522 @default.
• W2007211412 cites W2030134162 @default.
• W2007211412 cites W2036869107 @default.
• W2007211412 cites W2040021502 @default.
• W2007211412 cites W2049317842 @default.
• W2007211412 cites W2049511526 @default.
• W2007211412 cites W2051473177 @default.
• W2007211412 cites W2051582011 @default.
• W2007211412 cites W2052884971 @default.
• W2007211412 cites W2065220948 @default.
• W2007211412 cites W2072565343 @default.
• W2007211412 cites W2073805066 @default.
• W2007211412 cites W2076523914 @default.
• W2007211412 cites W2077758457 @default.
• W2007211412 cites W2094988830 @default.
• W2007211412 cites W2095103695 @default.
• W2007211412 cites W2103861118 @default.
• W2007211412 cites W2120905810 @default.
• W2007211412 cites W2123099861 @default.
• W2007211412 cites W2127072403 @default.
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• W2007211412 cites W2133459825 @default.
• W2007211412 cites W2142664907 @default.
• W2007211412 cites W2148389554 @default.
• W2007211412 cites W2149623272 @default.
• W2007211412 cites W2154639805 @default.
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• W2007211412 cites W2172253704 @default.
• W2007211412 cites W2333717658 @default.
• W2007211412 cites W2405663256 @default.
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• W2007211412 cites W3021526609 @default.
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• W2007211412 doi "https://doi.org/10.1002/hipo.10032" @default.
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