FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007215767> ?p ?o ?g. }

• W2007215767 endingPage "3181" @default.
• W2007215767 startingPage "3171" @default.
• W2007215767 abstract "Abstract Patch‐clamp techniques and Ca 2+ imaging were used to examine the interaction between neurokinins (NK) and the capsaicin (CAPS)‐evoked transient receptor potential vanilloid receptor 1 (TRPV1) responses in rat dorsal root ganglia neurons. Substance P (SP; 0.2–0.5 μ m ) prevented the reduction of Ca 2+ transients (tachyphylaxis) evoked by repeated brief applications of CAPS (0.5 μ m ). Currents elicited by CAPS were increased in amplitude and desensitized more slowly after administration of SP or a selective NK 2 agonist, [Ala 8 ]‐neurokinin A (4–10) (NKA). Neither an NK 1 ‐selective agonist, [Sar 9 , Met 11 ]‐SP, nor an NK 3 ‐selective agonist, [MePhe 7 ]‐NKB, altered the CAPS currents. The effects of SP on CAPS currents were inhibited by a selective NK 2 antagonist, MEN 10,376, but were unaffected by the NK 3 antagonist, SB 235,375. Phorbol 12,13‐dibutyrate (PDBu), an activator of protein kinase C (PKC), also increased the amplitude and slowed the desensitization of CAPS responses. Phosphatase inhibitors, decamethrin and α‐naphthyl acid phosphate (NAcPh), also enhanced the currents and slowed desensitization of CAPS currents. Facilitatory effects of SP, NKA and PDBu were reversed by bisindolylmaleimide, a PKC inhibitor, and gradually decreased in magnitude when the agents were administered at increasing intervals after CAPS application. The decrease was partially prevented by prior application of NAcPh. These data suggest that activation of NK 2 receptors in afferent neurons leads to PKC‐induced phosphorylation of TRPV1, resulting in sensitization of CAPS‐evoked currents and slower desensitization. Thus, activation of NK 2 autoreceptors by NKs released from the peripheral afferent terminals or by mast cells during inflammatory responses may be a mechanism that sensitizes TRPV1 channels and enhances afferent excitability." @default.
• W2007215767 created "2016-06-24" @default.
• W2007215767 creator A5018950717 @default.
• W2007215767 creator A5031171170 @default.
• W2007215767 creator A5078179672 @default.
• W2007215767 date "2008-06-01" @default.
• W2007215767 modified "2023-10-14" @default.
• W2007215767 title "Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats" @default.
• W2007215767 cites W1492591187 @default.
• W2007215767 cites W1511198581 @default.
• W2007215767 cites W1883732752 @default.
• W2007215767 cites W1952328179 @default.
• W2007215767 cites W1968300686 @default.
• W2007215767 cites W1970612797 @default.
• W2007215767 cites W1971754431 @default.
• W2007215767 cites W1973556415 @default.
• W2007215767 cites W1974620224 @default.
• W2007215767 cites W1981333657 @default.
• W2007215767 cites W1984033377 @default.
• W2007215767 cites W1986235007 @default.
• W2007215767 cites W1991417446 @default.
• W2007215767 cites W1994266757 @default.
• W2007215767 cites W1999939316 @default.
• W2007215767 cites W2001691754 @default.
• W2007215767 cites W2004728887 @default.
• W2007215767 cites W2018281052 @default.
• W2007215767 cites W2022835487 @default.
• W2007215767 cites W2032797890 @default.
• W2007215767 cites W2036820543 @default.
• W2007215767 cites W2039522435 @default.
• W2007215767 cites W2046403343 @default.
• W2007215767 cites W2047754566 @default.
• W2007215767 cites W2049100687 @default.
• W2007215767 cites W2053539033 @default.
• W2007215767 cites W2062480940 @default.
• W2007215767 cites W2062606765 @default.
• W2007215767 cites W2068156464 @default.
• W2007215767 cites W2073644466 @default.
• W2007215767 cites W2075831855 @default.
• W2007215767 cites W2076733846 @default.
• W2007215767 cites W2079063759 @default.
• W2007215767 cites W2087677022 @default.
• W2007215767 cites W2089633836 @default.
• W2007215767 cites W2094681881 @default.
• W2007215767 cites W2109293109 @default.
• W2007215767 cites W2127140021 @default.
• W2007215767 cites W2135567029 @default.
• W2007215767 cites W2149487756 @default.
• W2007215767 cites W2150617526 @default.
• W2007215767 cites W2163050322 @default.
• W2007215767 cites W2164144654 @default.
• W2007215767 cites W2166235950 @default.
• W2007215767 cites W2951198839 @default.
• W2007215767 cites W4248105561 @default.
• W2007215767 doi "https://doi.org/10.1111/j.1460-9568.2008.06267.x" @default.
• W2007215767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2896238" @default.
• W2007215767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18598261" @default.
• W2007215767 hasPublicationYear "2008" @default.
• W2007215767 type Work @default.
• W2007215767 sameAs 2007215767 @default.
• W2007215767 citedByCount "48" @default.
• W2007215767 countsByYear W20072157672012 @default.
• W2007215767 countsByYear W20072157672013 @default.
• W2007215767 countsByYear W20072157672014 @default.
• W2007215767 countsByYear W20072157672015 @default.
• W2007215767 countsByYear W20072157672016 @default.
• W2007215767 countsByYear W20072157672017 @default.
• W2007215767 countsByYear W20072157672018 @default.
• W2007215767 countsByYear W20072157672019 @default.
• W2007215767 countsByYear W20072157672020 @default.
• W2007215767 countsByYear W20072157672021 @default.
• W2007215767 countsByYear W20072157672022 @default.
• W2007215767 countsByYear W20072157672023 @default.
• W2007215767 crossrefType "journal-article" @default.
• W2007215767 hasAuthorship W2007215767A5018950717 @default.
• W2007215767 hasAuthorship W2007215767A5031171170 @default.
• W2007215767 hasAuthorship W2007215767A5078179672 @default.
• W2007215767 hasBestOaLocation W20072157672 @default.
• W2007215767 hasConcept C118303440 @default.
• W2007215767 hasConcept C11960822 @default.
• W2007215767 hasConcept C126322002 @default.
• W2007215767 hasConcept C134018914 @default.
• W2007215767 hasConcept C147944092 @default.
• W2007215767 hasConcept C155164980 @default.
• W2007215767 hasConcept C160145004 @default.
• W2007215767 hasConcept C168481208 @default.
• W2007215767 hasConcept C170493617 @default.
• W2007215767 hasConcept C185592680 @default.
• W2007215767 hasConcept C195794163 @default.
• W2007215767 hasConcept C2776533618 @default.
• W2007215767 hasConcept C2776885963 @default.
• W2007215767 hasConcept C2777056410 @default.
• W2007215767 hasConcept C2777314051 @default.
• W2007215767 hasConcept C2778938600 @default.
• W2007215767 hasConcept C2779779143 @default.
• W2007215767 hasConcept C2780051329 @default.
• W2007215767 hasConcept C55493867 @default.
• W2007215767 hasConcept C71924100 @default.

• next