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- W2007216973 abstract "Abstract Isoproterenol was found to have produced adverse reactions in eight of our patients. All demonstrated large negative ST segment shifts. In experimental studies in rats, the J-shift of the electrocardiogram was sensitive to low doses of isoproterenol. Combined use of a nitrate and beta-blocker completely reversed the significant negative J-shift depression induced by isoproterenol. Dog studies using platinum electrodes to measure intramyocardial oxygen tension at the epicardium and endocardium documented an intracardiac diversion of blood flow between the subendocardium and subepicardium. Isoproterenol diverted blood flow away from the subendocardium, which is very vulnerable to ischemia and decreased perfusion. This isoproterenol-induced “coronary steal” is probably due to localized hypoxia at the subendocardium. Nitroglycerin and propranolol both selectively increased subendocardial blood flow with little effect at the subepicardium. The regulation of blood flow through the coronary circulation can be explained in part by an intramyocardial diversion phenomenon." @default.
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- W2007216973 date "1975-05-01" @default.
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- W2007216973 title "Intramyocardial diversion of coronary blood flow: Effects of isoproterenol-induced subendocardial ischemia" @default.
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- W2007216973 doi "https://doi.org/10.1016/0026-2862(75)90063-1" @default.
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