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- W2007217839 abstract "Sir, Dr Greenberg has unfortunately misinterpreted some of our data or looked at them rather narrowly. He raises the following four points with respect to our conclusions drawn from our results: 1. Dr Greenberg argues that immune cells produce amyloid precursor protein (APP) and suggests that a correlation between APP and inflammatory mediators would hence be expected. This is true and in line with our immunohistochemical analysis as shown in Fig. 2B (Schmidt et al. , 2008). Probably Dr Greenberg did not appreciate that Fig 2B clearly demonstrates that the majority of the staining signal of APP in sIBM derives from the muscle fibres while the contribution by immune cells is minimal. The production of APP by the muscle fibres themselves was further substantiated by our in vitro experiments with exposure of muscle cells to IL-1β and IFN-γ (Fig. 5A and B).2. Dr Greenberg notes that after removing the outlier, there is a significant correlation between IL-1β and APP in PM. This is true, but we had already pointed …" @default.
- W2007217839 created "2016-06-24" @default.
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- W2007217839 date "2008-05-21" @default.
- W2007217839 modified "2023-09-27" @default.
- W2007217839 title "Inflammation interrelates to APP in sIBM: IL-1 induces accumulation of -amyloid" @default.
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- W2007217839 doi "https://doi.org/10.1093/brain/awn164" @default.
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