Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007219210> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2007219210 endingPage "1890" @default.
- W2007219210 startingPage "1888" @default.
- W2007219210 abstract "We have established a system of efficient gene transfer to liver grafts using adenovirus vectors. The purpose of this study was to examine variables affecting gene transfer to rat liver grafts during cold preservation. Our results demonstrate that gene transfer efficiency was directly correlated with the ratio of vector to hepatic cells (multiplicity of infection [MOI]) and the length of exposure to the vector. At MOls of 101 and 501, the hepatic cell transduction rate was 25-30% and 10%, respectively. However, higher MOI was associated with significant mortality. Prolonging the cold preservation/exposure time resulted in an increased transduction rate (50% at MOI of 10:1). Similar gene transfer efficiencies were observed when the vector was diluted in lactated Ringer's or University of Wisconsin solution. Recombinant protein production was evident within 12 hr after reperfusion, and increased to a peak level within 48 hr. These results suggest a predictable pattern of gene transfer and expression after ex vivo transduction of liver grafts with adenovirus vectors. These data are es sential in directing desirable levels of recombinant protein within the transplanted organ." @default.
- W2007219210 created "2016-06-24" @default.
- W2007219210 creator A5046543120 @default.
- W2007219210 creator A5055510159 @default.
- W2007219210 date "1995-12-01" @default.
- W2007219210 modified "2023-09-23" @default.
- W2007219210 title "Can a guest liver bring the gift of a gene to disarm a hostile host?" @default.
- W2007219210 cites W1652473508 @default.
- W2007219210 cites W1977635226 @default.
- W2007219210 cites W1978954387 @default.
- W2007219210 cites W1979541866 @default.
- W2007219210 cites W2013359336 @default.
- W2007219210 cites W2037626742 @default.
- W2007219210 cites W2058441058 @default.
- W2007219210 cites W2077389439 @default.
- W2007219210 cites W2088049380 @default.
- W2007219210 cites W2094646089 @default.
- W2007219210 cites W2166797660 @default.
- W2007219210 cites W4243138485 @default.
- W2007219210 cites W4253823322 @default.
- W2007219210 doi "https://doi.org/10.1002/hep.1840220641" @default.
- W2007219210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7490004" @default.
- W2007219210 hasPublicationYear "1995" @default.
- W2007219210 type Work @default.
- W2007219210 sameAs 2007219210 @default.
- W2007219210 citedByCount "0" @default.
- W2007219210 crossrefType "journal-article" @default.
- W2007219210 hasAuthorship W2007219210A5046543120 @default.
- W2007219210 hasAuthorship W2007219210A5055510159 @default.
- W2007219210 hasBestOaLocation W20072192101 @default.
- W2007219210 hasConcept C104317684 @default.
- W2007219210 hasConcept C111599444 @default.
- W2007219210 hasConcept C15152581 @default.
- W2007219210 hasConcept C153911025 @default.
- W2007219210 hasConcept C16685009 @default.
- W2007219210 hasConcept C185592680 @default.
- W2007219210 hasConcept C203233990 @default.
- W2007219210 hasConcept C207001950 @default.
- W2007219210 hasConcept C26291073 @default.
- W2007219210 hasConcept C3018928802 @default.
- W2007219210 hasConcept C32470452 @default.
- W2007219210 hasConcept C40767141 @default.
- W2007219210 hasConcept C54355233 @default.
- W2007219210 hasConcept C55493867 @default.
- W2007219210 hasConcept C71924100 @default.
- W2007219210 hasConcept C86803240 @default.
- W2007219210 hasConcept C95444343 @default.
- W2007219210 hasConceptScore W2007219210C104317684 @default.
- W2007219210 hasConceptScore W2007219210C111599444 @default.
- W2007219210 hasConceptScore W2007219210C15152581 @default.
- W2007219210 hasConceptScore W2007219210C153911025 @default.
- W2007219210 hasConceptScore W2007219210C16685009 @default.
- W2007219210 hasConceptScore W2007219210C185592680 @default.
- W2007219210 hasConceptScore W2007219210C203233990 @default.
- W2007219210 hasConceptScore W2007219210C207001950 @default.
- W2007219210 hasConceptScore W2007219210C26291073 @default.
- W2007219210 hasConceptScore W2007219210C3018928802 @default.
- W2007219210 hasConceptScore W2007219210C32470452 @default.
- W2007219210 hasConceptScore W2007219210C40767141 @default.
- W2007219210 hasConceptScore W2007219210C54355233 @default.
- W2007219210 hasConceptScore W2007219210C55493867 @default.
- W2007219210 hasConceptScore W2007219210C71924100 @default.
- W2007219210 hasConceptScore W2007219210C86803240 @default.
- W2007219210 hasConceptScore W2007219210C95444343 @default.
- W2007219210 hasIssue "6" @default.
- W2007219210 hasLocation W20072192101 @default.
- W2007219210 hasLocation W20072192102 @default.
- W2007219210 hasOpenAccess W2007219210 @default.
- W2007219210 hasPrimaryLocation W20072192101 @default.
- W2007219210 hasRelatedWork W1977635226 @default.
- W2007219210 hasRelatedWork W1988758419 @default.
- W2007219210 hasRelatedWork W2006394078 @default.
- W2007219210 hasRelatedWork W2007219210 @default.
- W2007219210 hasRelatedWork W2037797928 @default.
- W2007219210 hasRelatedWork W2207539842 @default.
- W2007219210 hasRelatedWork W2385911569 @default.
- W2007219210 hasRelatedWork W2387639147 @default.
- W2007219210 hasRelatedWork W2520720195 @default.
- W2007219210 hasRelatedWork W4252405008 @default.
- W2007219210 hasVolume "22" @default.
- W2007219210 isParatext "false" @default.
- W2007219210 isRetracted "false" @default.
- W2007219210 magId "2007219210" @default.
- W2007219210 workType "article" @default.