FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007220609> ?p ?o ?g. }

• W2007220609 endingPage "1153" @default.
• W2007220609 startingPage "1144" @default.
• W2007220609 abstract "In eubacteria, termination of translation is signaled by any one of the stop codons UAA, UAG, and UGA moving into the ribosomal A site. Two release factors, RF1 and RF2, recognize and bind to the stop codons with different affinities and trigger the hydrolysis of the ester bond that links the polypeptide with the P-site tRNA. Cryo-electron microscopy (cryo-EM) results obtained in this study show that ribosome-bound RF1 is in an open conformation, unlike the closed conformation observed in the crystal structure of the free factor, allowing its simultaneous access to both the decoding center and the peptidyl-transferase center. These results are similar to those obtained for RF2, but there is an important difference in how the factors bind to protein L11, which forms part of the GTPase-associated center of the large ribosomal subunit. The difference in the binding position, C-terminal domain for RF2 versus N-terminal domain for RF1, explains a body of L11 mutation studies that revealed differential effects on the activity of the two factors. Very recent data obtained with small-angle X-ray scattering now reveal that the solution structure of RF1 is open, as here seen on the ribosome by cryo-EM, and not closed, as seen in the crystal." @default.
• W2007220609 created "2016-06-24" @default.
• W2007220609 creator A5012481592 @default.
• W2007220609 creator A5018995016 @default.
• W2007220609 creator A5034965755 @default.
• W2007220609 creator A5042892654 @default.
• W2007220609 creator A5079066005 @default.
• W2007220609 creator A5089849555 @default.
• W2007220609 date "2006-04-01" @default.
• W2007220609 modified "2023-10-02" @default.
• W2007220609 title "Interactions of the Release Factor RF1 with the Ribosome as Revealed by Cryo-EM" @default.
• W2007220609 cites W1536862045 @default.
• W2007220609 cites W1594797965 @default.
• W2007220609 cites W1605208286 @default.
• W2007220609 cites W1642698206 @default.
• W2007220609 cites W1679770227 @default.
• W2007220609 cites W1943865121 @default.
• W2007220609 cites W1965257507 @default.
• W2007220609 cites W1969172282 @default.
• W2007220609 cites W1975924299 @default.
• W2007220609 cites W1984936999 @default.
• W2007220609 cites W2002193643 @default.
• W2007220609 cites W2012879549 @default.
• W2007220609 cites W2013083986 @default.
• W2007220609 cites W2016661131 @default.
• W2007220609 cites W2020942151 @default.
• W2007220609 cites W2037758583 @default.
• W2007220609 cites W2038937120 @default.
• W2007220609 cites W2046889198 @default.
• W2007220609 cites W2048982317 @default.
• W2007220609 cites W2054702783 @default.
• W2007220609 cites W2061327322 @default.
• W2007220609 cites W2062756298 @default.
• W2007220609 cites W2074989746 @default.
• W2007220609 cites W2081540493 @default.
• W2007220609 cites W2093471887 @default.
• W2007220609 cites W2094987467 @default.
• W2007220609 cites W2122049445 @default.
• W2007220609 cites W2129096064 @default.
• W2007220609 cites W2132261408 @default.
• W2007220609 cites W2135985251 @default.
• W2007220609 cites W2136211980 @default.
• W2007220609 cites W2137206793 @default.
• W2007220609 cites W2139530620 @default.
• W2007220609 cites W2152348402 @default.
• W2007220609 cites W2165165230 @default.
• W2007220609 cites W2166905169 @default.
• W2007220609 doi "https://doi.org/10.1016/j.jmb.2006.01.038" @default.
• W2007220609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16476444" @default.
• W2007220609 hasPublicationYear "2006" @default.
• W2007220609 type Work @default.
• W2007220609 sameAs 2007220609 @default.
• W2007220609 citedByCount "68" @default.
• W2007220609 countsByYear W20072206092012 @default.
• W2007220609 countsByYear W20072206092013 @default.
• W2007220609 countsByYear W20072206092014 @default.
• W2007220609 countsByYear W20072206092015 @default.
• W2007220609 countsByYear W20072206092016 @default.
• W2007220609 countsByYear W20072206092017 @default.
• W2007220609 countsByYear W20072206092018 @default.
• W2007220609 countsByYear W20072206092019 @default.
• W2007220609 countsByYear W20072206092020 @default.
• W2007220609 countsByYear W20072206092021 @default.
• W2007220609 crossrefType "journal-article" @default.
• W2007220609 hasAuthorship W2007220609A5012481592 @default.
• W2007220609 hasAuthorship W2007220609A5018995016 @default.
• W2007220609 hasAuthorship W2007220609A5034965755 @default.
• W2007220609 hasAuthorship W2007220609A5042892654 @default.
• W2007220609 hasAuthorship W2007220609A5079066005 @default.
• W2007220609 hasAuthorship W2007220609A5089849555 @default.
• W2007220609 hasConcept C104317684 @default.
• W2007220609 hasConcept C105580179 @default.
• W2007220609 hasConcept C106774688 @default.
• W2007220609 hasConcept C107824862 @default.
• W2007220609 hasConcept C12554922 @default.
• W2007220609 hasConcept C129194359 @default.
• W2007220609 hasConcept C149364088 @default.
• W2007220609 hasConcept C153957851 @default.
• W2007220609 hasConcept C185592680 @default.
• W2007220609 hasConcept C20702342 @default.
• W2007220609 hasConcept C2778321597 @default.
• W2007220609 hasConcept C2779498050 @default.
• W2007220609 hasConcept C38062823 @default.
• W2007220609 hasConcept C55493867 @default.
• W2007220609 hasConcept C67705224 @default.
• W2007220609 hasConcept C67905577 @default.
• W2007220609 hasConcept C69080955 @default.
• W2007220609 hasConcept C8010536 @default.
• W2007220609 hasConcept C86803240 @default.
• W2007220609 hasConcept C88478588 @default.
• W2007220609 hasConcept C96267730 @default.
• W2007220609 hasConceptScore W2007220609C104317684 @default.
• W2007220609 hasConceptScore W2007220609C105580179 @default.
• W2007220609 hasConceptScore W2007220609C106774688 @default.
• W2007220609 hasConceptScore W2007220609C107824862 @default.
• W2007220609 hasConceptScore W2007220609C12554922 @default.
• W2007220609 hasConceptScore W2007220609C129194359 @default.
• W2007220609 hasConceptScore W2007220609C149364088 @default.

• next