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- W2007225441 abstract "La vitamina D (VitD), además de su papel en el metabolismo mineral, tiene funciones inmunomoduladoras y podría participar activamente en la fisiopatogénesis de la infección por el VIH-1; sin embargo, la evidencia científica en este campo es limitada y controvertida. La VitD tiene propiedades antiinflamatorias que podrían disminuir la hiperactivación inmunológica, reduciendo el daño asociado a este fenómeno; además, promueve la expresión de péptidos con actividad anti-VIH-1, sustentando su papel protector. En contraste, la VitD activa el promotor del VIH-1 y podría potenciar la replicación del virus; adicionalmente, algunas variantes alélicas en el gen del receptor de la VitD, que aumentan su función, se han asociado con susceptibilidad al VIH-1. Esta revisión presenta evidencia científica sobre el efecto de la vía de la VitD en la patogénesis de la infección por el VIH-1, dada las implicaciones de este tópico en la identificación de nuevos blancos terapéuticos en esta infección. Beyond its role in mineral metabolism, vitamin D (VitD) has immunomodulatory functions and can actively participate in the physiopathogenesis of HIV-1 infection; however, scientific evidence in this field is limited and controversial. VitD has anti-inflammatory properties that can reduce immune hyperactivation, decreasing the damage associated with this phenomenon. It also promotes the expression of antimicrobial peptides with anti-HIV-1 activity, supporting its protective role. In contrast, VitD activates the HIV-1 promoter and can increase viral replication. Furthermore, a number of allelic variants in the vitamin D receptor gene, which increase its function, have been associated with susceptibility to HIV-1 infection. Given the implications of this topic for the identification of new therapeutic targets in HIV infection, this review presents scientific evidence on the effect of the VitD pathway in HIV-1 pathogenesis." @default.
- W2007225441 created "2016-06-24" @default.
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- W2007225441 date "2013-07-01" @default.
- W2007225441 modified "2023-09-23" @default.
- W2007225441 title "Participación de la vitamina D en la patogénesis de la infección por el virus de la inmunodeficiencia humana tipo 1" @default.
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