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- W200722710 abstract "Abstract The c-fms protooncogene product was identified as the CSF-1 or M-CSF receptor, a polypeptide growth factor that plays a major role in myelomonocytic differentiation. This led us to look for expression of c- fms in fresh acute myeloid leukemia (AML) cells, using Northern blot analysis. c-fms expression was found in the leukemic cells of 28 AML patients, regardless of their stage of differentiation, which was assessed in the French-American-British (FAB) classification. However, the level of c-fms expression was especially high in AML of the M5 stage. High levels of expression were not accompanied by either amplification or rearrangements of the c-fms gene in AML cell DNAs. In contrast, c-fms expression was not found in acute lymphoid leukemias, whether of T or B origin. Thus, c-fms expression appears as a specific molecular marker of leukemogenesis in the myeloid lineage." @default.
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- W200722710 date "1988-09-01" @default.
- W200722710 modified "2023-09-27" @default.
- W200722710 title "c-fms expression is a molecular marker of human acute myeloid leukemias" @default.
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- W200722710 doi "https://doi.org/10.1182/blood.v72.3.1081.1081" @default.
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