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• W2007230611 abstract "Peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) promotes the expression of oxidative enzymes in skeletal muscle. We hypothesized that activation of the p38 MAPK (mitogen-activated protein kinase) in response to exercise was associated with exercise-induced PGC-1alpha and respiratory enzymes expression and aimed to demonstrate this under the physiological level. We subjected mice to a single bout of treadmill running and found that the exercise induced a biphasic increase in the expression of respiratory enzymes mRNA. The second phase of the increase was accompanied by an increase in PGC-1alpha protein, but the other was not. Administration of SB203580 (SB), an inhibitor of p38 MAPK, suppressed the increase in PGC-1alpha expression and respiratory enzymes mRNA in both phases. These data suggest that p38 MAPK is associated with the exercise-induced expression of PGC-1alpha and biphasic increase in respiratory enzyme mRNAs in mouse skeletal muscle under physiological conditions." @default.
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• W2007230611 date "2008-04-01" @default.
• W2007230611 modified "2023-10-18" @default.
• W2007230611 title "Acute exercise induces biphasic increase in respiratory mRNA in skeletal muscle" @default.
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• W2007230611 doi "https://doi.org/10.1016/j.bbrc.2008.01.095" @default.
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