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• W2007235781 abstract "The synthesis and structure-activity relationships (SAR) of a series of pyrrolidine-3-carboxylic acids as endothelin antagonists are described. The data shows an increase in selectivity when the methoxy of Atrasentan (ABT-627) is replaced with methyl, and the benzodioxole is replaced with dihydrobenzofuran. Adding a fluorine further increases the binding activity and provides a metabolically stable and orally bioavailable ET(A)-selective antagonist." @default.
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• W2007235781 date "2001-10-04" @default.
• W2007235781 modified "2023-10-07" @default.
• W2007235781 title "Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 5. Highly Selective, Potent, and Orally Active ET_A Antagonists" @default.
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• W2007235781 doi "https://doi.org/10.1021/jm010237l" @default.
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