FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007237194> ?p ?o ?g. }

• W2007237194 endingPage "2028" @default.
• W2007237194 startingPage "2021" @default.
• W2007237194 abstract "Necrosis is a characteristic feature of advanced solid tumors. Released necrotic factors, also referred to as damage associated molecular patterns (DAMPs), are known to critically impact the tumor microenvironment by enhancing angiogenesis or influencing the immune response. We have recently shown that DAMPs can act as chemoattractants and activators of granulocytes. We demonstrate that necrotic material from both normal and tumor cells promotes proliferation and trafficking of human mesenchymal stem cells (MSCs). We characterize the protein high mobility group box 1 (HMGB1) as a crucial member of DAMPs within necrotic material. In addition, we show that DAMPs interfere with expression of indoleamine 2, 3-dioxygenase (IDO) in MSCs. The biological activity of necrotic material toward MSCs is abolished once these DAMPs are oxidized. MSCs found within tumor tissue can act as immunoregulatory cells and are able to promote tumor metastasis, thus playing a crucial role within the tumor microenvironment. Here, we reveal DAMPs to be crucial factors in the setting of MSC biology within the tumor microenvironment. The tumor microenvironment is characterized by reducing and hypoxic conditions that protect DAMPs from oxidation. Based on our results, oxidizing conditions should be considered for therapeutic approaches that target the tumor microenvironment." @default.
• W2007237194 created "2016-06-24" @default.
• W2007237194 creator A5007372145 @default.
• W2007237194 creator A5040151109 @default.
• W2007237194 creator A5042093319 @default.
• W2007237194 creator A5048255612 @default.
• W2007237194 creator A5062529936 @default.
• W2007237194 creator A5068469918 @default.
• W2007237194 creator A5071299751 @default.
• W2007237194 creator A5071868326 @default.
• W2007237194 date "2011-06-27" @default.
• W2007237194 modified "2023-10-16" @default.
• W2007237194 title "Human mesenchymal stem cells respond to native but not oxidized damage associated molecular pattern molecules from necrotic (tumor) material" @default.
• W2007237194 cites W1565329973 @default.
• W2007237194 cites W1583109269 @default.
• W2007237194 cites W1979704965 @default.
• W2007237194 cites W1986047336 @default.
• W2007237194 cites W2004266769 @default.
• W2007237194 cites W2018411113 @default.
• W2007237194 cites W2019495971 @default.
• W2007237194 cites W2028239901 @default.
• W2007237194 cites W2030653181 @default.
• W2007237194 cites W2059467769 @default.
• W2007237194 cites W206590346 @default.
• W2007237194 cites W2069598912 @default.
• W2007237194 cites W2083245325 @default.
• W2007237194 cites W2085959362 @default.
• W2007237194 cites W2103276204 @default.
• W2007237194 cites W2104295191 @default.
• W2007237194 cites W2136299255 @default.
• W2007237194 cites W2141815918 @default.
• W2007237194 cites W2142678690 @default.
• W2007237194 cites W2149287721 @default.
• W2007237194 cites W2157579772 @default.
• W2007237194 cites W2159999899 @default.
• W2007237194 cites W2163828684 @default.
• W2007237194 doi "https://doi.org/10.1002/eji.201041324" @default.
• W2007237194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21538978" @default.
• W2007237194 hasPublicationYear "2011" @default.
• W2007237194 type Work @default.
• W2007237194 sameAs 2007237194 @default.
• W2007237194 citedByCount "59" @default.
• W2007237194 countsByYear W20072371942012 @default.
• W2007237194 countsByYear W20072371942013 @default.
• W2007237194 countsByYear W20072371942014 @default.
• W2007237194 countsByYear W20072371942015 @default.
• W2007237194 countsByYear W20072371942016 @default.
• W2007237194 countsByYear W20072371942017 @default.
• W2007237194 countsByYear W20072371942018 @default.
• W2007237194 countsByYear W20072371942019 @default.
• W2007237194 countsByYear W20072371942020 @default.
• W2007237194 countsByYear W20072371942022 @default.
• W2007237194 countsByYear W20072371942023 @default.
• W2007237194 crossrefType "journal-article" @default.
• W2007237194 hasAuthorship W2007237194A5007372145 @default.
• W2007237194 hasAuthorship W2007237194A5040151109 @default.
• W2007237194 hasAuthorship W2007237194A5042093319 @default.
• W2007237194 hasAuthorship W2007237194A5048255612 @default.
• W2007237194 hasAuthorship W2007237194A5062529936 @default.
• W2007237194 hasAuthorship W2007237194A5068469918 @default.
• W2007237194 hasAuthorship W2007237194A5071299751 @default.
• W2007237194 hasAuthorship W2007237194A5071868326 @default.
• W2007237194 hasBestOaLocation W20072371941 @default.
• W2007237194 hasConcept C121608353 @default.
• W2007237194 hasConcept C170493617 @default.
• W2007237194 hasConcept C17991360 @default.
• W2007237194 hasConcept C198826908 @default.
• W2007237194 hasConcept C203014093 @default.
• W2007237194 hasConcept C2776107976 @default.
• W2007237194 hasConcept C2776914184 @default.
• W2007237194 hasConcept C2779013556 @default.
• W2007237194 hasConcept C2780394083 @default.
• W2007237194 hasConcept C2780545709 @default.
• W2007237194 hasConcept C502942594 @default.
• W2007237194 hasConcept C54166955 @default.
• W2007237194 hasConcept C54355233 @default.
• W2007237194 hasConcept C55493867 @default.
• W2007237194 hasConcept C86803240 @default.
• W2007237194 hasConcept C8891405 @default.
• W2007237194 hasConcept C95444343 @default.
• W2007237194 hasConceptScore W2007237194C121608353 @default.
• W2007237194 hasConceptScore W2007237194C170493617 @default.
• W2007237194 hasConceptScore W2007237194C17991360 @default.
• W2007237194 hasConceptScore W2007237194C198826908 @default.
• W2007237194 hasConceptScore W2007237194C203014093 @default.
• W2007237194 hasConceptScore W2007237194C2776107976 @default.
• W2007237194 hasConceptScore W2007237194C2776914184 @default.
• W2007237194 hasConceptScore W2007237194C2779013556 @default.
• W2007237194 hasConceptScore W2007237194C2780394083 @default.
• W2007237194 hasConceptScore W2007237194C2780545709 @default.
• W2007237194 hasConceptScore W2007237194C502942594 @default.
• W2007237194 hasConceptScore W2007237194C54166955 @default.
• W2007237194 hasConceptScore W2007237194C54355233 @default.
• W2007237194 hasConceptScore W2007237194C55493867 @default.
• W2007237194 hasConceptScore W2007237194C86803240 @default.
• W2007237194 hasConceptScore W2007237194C8891405 @default.
• W2007237194 hasConceptScore W2007237194C95444343 @default.
• W2007237194 hasIssue "7" @default.

• next