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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007248897> ?p ?o ?g. }

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• W2007248897 abstract "Deregulation of the receptor tyrosine kinase c-Met has been implicated in human cancers. Pyrazolones with N-1 bearing a pendent hydroxyalkyl side chain showed selective inhibition of c-Met over VEGFR2. However, studies revealed the generation of active, nonselective metabolites. Blocking this metabolic hot spot led to the discovery of 17 (AMG 458). When dosed orally, 17 significantly inhibited tumor growth in the NIH3T3/TPR-Met and U-87 MG xenograft models with no adverse effect on body weight." @default.
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• W2007248897 date "2008-07-01" @default.
• W2007248897 modified "2023-10-08" @default.
• W2007248897 title "Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-<i>N</i>-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1<i>H</i>-pyrazole-4-carboxamide (AMG 458)" @default.
• W2007248897 doi "https://doi.org/10.1021/jm800401t" @default.
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