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- W2007249947 abstract "Human immunodeficiency virus type 1 (HIV-1) group M is responsible for the current AIDS pandemic and exhibits exceedingly high levels of viral genetic diversity around the world, necessitating categorization of viruses into distinct lineages, or subtypes. These subtypes can differ by around 35% in the envelope (Env) glycoproteins of the virus, which are displayed on the surface of the virion and are targets for both neutralizing antibody and cell-mediated immune responses. This diversity reflects the remarkable ability of the virus to adapt to selective pressures, the bulk of which is applied by the host immune response, and represents a serious obstacle for developing an effective vaccine with broad coverage. Thus, it is important to understand the underlying biological consequences of intersubtype diversity. Recent studies have revealed that some of the HIV-1 subtypes exhibit phenotypic differences stemming from subtle changes in Env structure, particularly within the highly immunogenic V3 domain, which participates directly in viral entry. This review will therefore explore current research that describes subtype differences in Env at the genetic and phenotypic level, focusing in particular on V3, and highlighting recent discoveries about the unique features of subtype C Env, which is the most globally prevalent subtype." @default.
- W2007249947 created "2016-06-24" @default.
- W2007249947 creator A5026220972 @default.
- W2007249947 creator A5028630257 @default.
- W2007249947 creator A5037917270 @default.
- W2007249947 creator A5078174602 @default.
- W2007249947 date "2009-03-01" @default.
- W2007249947 modified "2023-10-14" @default.
- W2007249947 title "Appreciating HIV Type 1 Diversity: Subtype Differences in Env" @default.
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