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- W2007249985 abstract "Characteristics of the binding of [3H]ramosetron to cloned human 5-hydroxytryptamine3 (5-HT3) receptors were investigated and directly compared to those of [3H]granisetron binding. Saturation studies revealed that [3H]ramosetron labeled more sites with high affinity (Kd=0.15+/-0.01 nM, Bmax =653 +/- 30 fmol/mg protein) than [3H]granisetron (Kd=1.17+/-0.25 nM, Bmax=427+/-43 fmol/mg protein). Kinetic studies revealed that dissociation of [3H]ramosetron was slower than that of [3H]granisetron. These results suggest that ramosetron is a highly potent 5-HT3-receptor antagonist." @default.
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- W2007249985 title "Comparative Study of [3H]Ramosetron and [3H]Granisetron Binding in the Cloned Human 5-Hydroxytryptamine3 Receptors" @default.
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- W2007249985 doi "https://doi.org/10.1254/jjp.78.381" @default.
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