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• W2007251119 abstract "Background and Objective Binding of human platelet antigen‐1a (HPA‐1a)‐specific antibodies to target platelets can trigger platelet activation and mediator release. Here we tested the effect of HPA‐1a antibody‐containing sera on platelet release of the chemokine RANTES (regulated on activation, normal, T‐cell expressed, and presumably secreted) in vitro . Patients and Methods HPA‐1a‐containing sera obtained from 11 mothers delivered of an infant with neonatal alloimmune thrombocytopenia (NAIT) and from six patients with post‐transfusion purpura (PTP) were incubated with HPA‐1a/a target platelets. Antibody‐induced release of soluble RANTES was determined by enzyme‐linked immunosorbent assay (ELISA). Results A significant release of soluble RANTES was induced by four out of the 17 sera. Two out of the four reactive sera were obtained from mothers who were delivered of a baby with NAIT and the remaining two sera were from patients with PTP. Chemokine release was specific for binding of anti‐HPA‐1a to the platelet membrane, as none of the reactive sera induced the release of soluble RANTES when incubated with HPA‐1b/b platelets. The blockade of platelet‐expressed Fc gamma receptor type II (FcγRII) inhibited anti‐HPA‐1a‐mediated RANTES release when incubated with the reactive sera of patients with NAIT, but not when platelets were incubated with sera of patients with PTP. Conclusion Our findings suggest that anti‐HPA‐1a antibody‐induced release of platelet‐derived RANTES can play a role in adverse reactions in alloimmunized patients." @default.
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• W2007251119 date "2001-10-01" @default.
• W2007251119 modified "2023-10-18" @default.
• W2007251119 title "Human platelet antigen-1a antibodies induce the release of the chemokine RANTES from human platelets" @default.
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• W2007251119 doi "https://doi.org/10.1046/j.0042-9007.2001.00105.x" @default.
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