FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007253279> ?p ?o ?g. }

• W2007253279 endingPage "552" @default.
• W2007253279 startingPage "545" @default.
• W2007253279 abstract "Psoriasis is a chronic inflammatory skin disease that affects 0.1%-5% depending on the population. PSORS1 is the major susceptibility locus, accounting for approximately 33%-50% of the genetic component of psoriasis among Caucasians. PSORS1 is located within the major histocompatibility complex (MHC) locus on 6p21.3. Its position has been refined to hundreds of kilobase and the region located at approximately 100-200 kb telomeric to human leukocyte antigen (HLA)-C is a very strong candidate. To determine the MHC psoriasis risk haplotype, we screened the whole 46 kb interval for single-nucleotide polymorphisms (SNP) and identified 138 SNP. We genotyped 29 SNP throughout this region in psoriatic nuclear families. We calculated the frequency of haplotypes generated by the 29 SNP using all genotyped founder individuals and found four common haplotype with frequency >0.10. We then used SNPtagger to derive the best six SNP and fed these into Transmit using 148 nuclear families. We found that CTGGAC haplotype is a single-point score haplotypes telomeric to HLA-C and gives a 1 df, chi2 of 50.27 (p<0.0001). Most importantly the six selected SNP accurately tagged the most common haplotype found in this region. Moreover, using the same program (Transmit) we show that the association with CTGGAC is higher than the one with HLA-Cw6 (chi2=10.53; p=0.0051). Our results give scores as high as the highest single-point scores suggesting that it is unlikely to be able to discriminate the origin of the association on this analysis on strength of association." @default.
• W2007253279 created "2016-06-24" @default.
• W2007253279 creator A5013148105 @default.
• W2007253279 creator A5026963044 @default.
• W2007253279 creator A5030539748 @default.
• W2007253279 creator A5030639968 @default.
• W2007253279 creator A5056139238 @default.
• W2007253279 creator A5061801225 @default.
• W2007253279 creator A5066596746 @default.
• W2007253279 creator A5068806445 @default.
• W2007253279 creator A5071898738 @default.
• W2007253279 creator A5079802026 @default.
• W2007253279 creator A5083806199 @default.
• W2007253279 creator A5085002158 @default.
• W2007253279 date "2005-03-01" @default.
• W2007253279 modified "2023-09-26" @default.
• W2007253279 title "Single-Point Haplotype Scores Telomeric to Human Leukocyte Antigen-C Give a High Susceptibility Major Histocompatability Complex Haplotype for Psoriasis in a Caucasian Population" @default.
• W2007253279 cites W1497954397 @default.
• W2007253279 cites W1566673175 @default.
• W2007253279 cites W1966007013 @default.
• W2007253279 cites W1967190331 @default.
• W2007253279 cites W1967877633 @default.
• W2007253279 cites W1984704099 @default.
• W2007253279 cites W2002564084 @default.
• W2007253279 cites W2006950321 @default.
• W2007253279 cites W2011354400 @default.
• W2007253279 cites W2016973078 @default.
• W2007253279 cites W2020446335 @default.
• W2007253279 cites W2032110831 @default.
• W2007253279 cites W2035464895 @default.
• W2007253279 cites W2038526670 @default.
• W2007253279 cites W2051174436 @default.
• W2007253279 cites W2054741047 @default.
• W2007253279 cites W2054861016 @default.
• W2007253279 cites W2059293441 @default.
• W2007253279 cites W2067724289 @default.
• W2007253279 cites W2071880067 @default.
• W2007253279 cites W2074574224 @default.
• W2007253279 cites W2076088878 @default.
• W2007253279 cites W2080167581 @default.
• W2007253279 cites W2086537750 @default.
• W2007253279 cites W2090326114 @default.
• W2007253279 cites W2091681488 @default.
• W2007253279 cites W2092836731 @default.
• W2007253279 cites W2093065038 @default.
• W2007253279 cites W2093794297 @default.
• W2007253279 cites W2097574142 @default.
• W2007253279 cites W2105025553 @default.
• W2007253279 cites W2111941261 @default.
• W2007253279 cites W2118479904 @default.
• W2007253279 cites W2120169468 @default.
• W2007253279 cites W2126965694 @default.
• W2007253279 cites W2127265198 @default.
• W2007253279 cites W2131098197 @default.
• W2007253279 cites W2138048215 @default.
• W2007253279 cites W2138470479 @default.
• W2007253279 cites W2143294211 @default.
• W2007253279 cites W2144911879 @default.
• W2007253279 cites W2151013280 @default.
• W2007253279 cites W2151541423 @default.
• W2007253279 cites W2159472846 @default.
• W2007253279 cites W2159487337 @default.
• W2007253279 cites W2163504863 @default.
• W2007253279 cites W4241367262 @default.
• W2007253279 cites W4247778217 @default.
• W2007253279 cites W46014023 @default.
• W2007253279 doi "https://doi.org/10.1111/j.0022-202x.2005.23604.x" @default.
• W2007253279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15737195" @default.
• W2007253279 hasPublicationYear "2005" @default.
• W2007253279 type Work @default.
• W2007253279 sameAs 2007253279 @default.
• W2007253279 citedByCount "11" @default.
• W2007253279 countsByYear W20072532792012 @default.
• W2007253279 countsByYear W20072532792013 @default.
• W2007253279 crossrefType "journal-article" @default.
• W2007253279 hasAuthorship W2007253279A5013148105 @default.
• W2007253279 hasAuthorship W2007253279A5026963044 @default.
• W2007253279 hasAuthorship W2007253279A5030539748 @default.
• W2007253279 hasAuthorship W2007253279A5030639968 @default.
• W2007253279 hasAuthorship W2007253279A5056139238 @default.
• W2007253279 hasAuthorship W2007253279A5061801225 @default.
• W2007253279 hasAuthorship W2007253279A5066596746 @default.
• W2007253279 hasAuthorship W2007253279A5068806445 @default.
• W2007253279 hasAuthorship W2007253279A5071898738 @default.
• W2007253279 hasAuthorship W2007253279A5079802026 @default.
• W2007253279 hasAuthorship W2007253279A5083806199 @default.
• W2007253279 hasAuthorship W2007253279A5085002158 @default.
• W2007253279 hasBestOaLocation W20072532791 @default.
• W2007253279 hasConcept C104317684 @default.
• W2007253279 hasConcept C135763542 @default.
• W2007253279 hasConcept C139275648 @default.
• W2007253279 hasConcept C147483822 @default.
• W2007253279 hasConcept C153209595 @default.
• W2007253279 hasConcept C188280979 @default.
• W2007253279 hasConcept C197754878 @default.
• W2007253279 hasConcept C203014093 @default.
• W2007253279 hasConcept C2780564577 @default.
• W2007253279 hasConcept C2908647359 @default.

• next