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- W2007254120 abstract "A series of DNA-binding potential antitumor agents bearing a cationic carboxamide side chain attached in position peri to an electron-withdrawing atom, N-5,2-di(omega-aminoalkyl)-2,6-dihydropyrazolo[3,4,5-kl]acridine-5-carboxamides, has been prepared by reaction of the appropriate 1-chloro-9-oxo-9,10-dihydro-4-acridinecarboxamides with the suitable (omega-aminoalkyl)hydrazine. The noncovalent DNA-binding properties of these compounds have been examined using a fluorometric technique. In vitro cytotoxic potency of these derivatives toward the human colon adenocarcinoma cell line (HT29) is described and compared to that of reference drugs. Structure-activity relationships are discussed. Two highly DNA-affinic and potent cytotoxic compounds, 4m,o, have been identified as new leads in the antitumor strategies." @default.
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- W2007254120 date "2001-08-31" @default.
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- W2007254120 title "Synthesis, Antitumor Cytotoxicity, and DNA-Binding of Novel <i>N-</i>5,2-Di(ω-aminoalkyl)-2,6-dihydropyrazolo[3,4,5-<i>kl</i>]acridine-5-carboxamides" @default.
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- W2007254120 doi "https://doi.org/10.1021/jm010917o" @default.
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