FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007257071> ?p ?o ?g. }

• W2007257071 endingPage "4305" @default.
• W2007257071 startingPage "4300" @default.
• W2007257071 abstract "3T3-F442A preadipocytes implanted s.c. into athymic mice develop into fat pads that are indistinguishable from normal adipose tissue. Implanted preadipocytes harboring a β-galactosidase transgene gave rise to fat pads in which almost all adipocytes expressed β-galactosidase. This finding proved that the implanted 3T3-F442A preadipocytes, rather than endogenous preadipose cells, gave rise to the newly developed “adipose tissue.” 3T3-F442A preadipocytes, when differentiated into adipocytes in cell culture, express the obese gene at an unexpectedly low level, i.e., ≤1% the level in adipose tissue. However, adipose tissue derived from s.c. implanted 3T3-F442A preadipocytes expressed leptin mRNA at a level comparable to that in epididymal adipose tissue. These findings indicate that a factor(s) or condition, present in the tissue context and necessary for maximal obese gene expression, is lacking in cell culture. Furthermore, adipocytes derived from the implanted cells were hormonally responsive in that leptin mRNA levels were up-regulated 3- to 8-fold by glucocorticoid injection into the host animal. Thus, these findings indicate that adipose-specific promoter–reporter constructs, transfected into 3T3-F442A preadipocytes, can be tested in an in vivo context during and after development of these cells into adipose tissue. Furthermore, the effect of transgenes on the adipogenic development of the implanted preadipocytes can be assessed. Thus, this approach offers a faster and less costly alternative to the transgenic mouse method for assessing adipose gene function." @default.
• W2007257071 created "2016-06-24" @default.
• W2007257071 creator A5012475457 @default.
• W2007257071 creator A5035669874 @default.
• W2007257071 creator A5064621414 @default.
• W2007257071 creator A5076507019 @default.
• W2007257071 creator A5077260684 @default.
• W2007257071 date "1997-04-29" @default.
• W2007257071 modified "2023-10-15" @default.
• W2007257071 title "Obese gene expression at <i>in vivo</i> levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes" @default.
• W2007257071 cites W1556721384 @default.
• W2007257071 cites W1647782814 @default.
• W2007257071 cites W1981073334 @default.
• W2007257071 cites W1986637319 @default.
• W2007257071 cites W1993203791 @default.
• W2007257071 cites W1996713062 @default.
• W2007257071 cites W2014669590 @default.
• W2007257071 cites W2016994959 @default.
• W2007257071 cites W2025846514 @default.
• W2007257071 cites W2043628605 @default.
• W2007257071 cites W2044153433 @default.
• W2007257071 cites W2053432905 @default.
• W2007257071 cites W2062001615 @default.
• W2007257071 cites W2063840236 @default.
• W2007257071 cites W2066231167 @default.
• W2007257071 cites W2078745862 @default.
• W2007257071 cites W2081426036 @default.
• W2007257071 cites W2089495913 @default.
• W2007257071 cites W2093371722 @default.
• W2007257071 cites W2094989225 @default.
• W2007257071 cites W2134812217 @default.
• W2007257071 cites W2159167752 @default.
• W2007257071 cites W2160635355 @default.
• W2007257071 cites W2164631596 @default.
• W2007257071 cites W2176176727 @default.
• W2007257071 cites W2259451302 @default.
• W2007257071 cites W4294216491 @default.
• W2007257071 doi "https://doi.org/10.1073/pnas.94.9.4300" @default.
• W2007257071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/20717" @default.
• W2007257071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9113984" @default.
• W2007257071 hasPublicationYear "1997" @default.
• W2007257071 type Work @default.
• W2007257071 sameAs 2007257071 @default.
• W2007257071 citedByCount "134" @default.
• W2007257071 countsByYear W20072570712012 @default.
• W2007257071 countsByYear W20072570712013 @default.
• W2007257071 countsByYear W20072570712014 @default.
• W2007257071 countsByYear W20072570712015 @default.
• W2007257071 countsByYear W20072570712016 @default.
• W2007257071 countsByYear W20072570712017 @default.
• W2007257071 countsByYear W20072570712018 @default.
• W2007257071 countsByYear W20072570712019 @default.
• W2007257071 countsByYear W20072570712020 @default.
• W2007257071 countsByYear W20072570712021 @default.
• W2007257071 countsByYear W20072570712022 @default.
• W2007257071 crossrefType "journal-article" @default.
• W2007257071 hasAuthorship W2007257071A5012475457 @default.
• W2007257071 hasAuthorship W2007257071A5035669874 @default.
• W2007257071 hasAuthorship W2007257071A5064621414 @default.
• W2007257071 hasAuthorship W2007257071A5076507019 @default.
• W2007257071 hasAuthorship W2007257071A5077260684 @default.
• W2007257071 hasBestOaLocation W20072570712 @default.
• W2007257071 hasConcept C102230213 @default.
• W2007257071 hasConcept C104317684 @default.
• W2007257071 hasConcept C122927707 @default.
• W2007257071 hasConcept C126322002 @default.
• W2007257071 hasConcept C134018914 @default.
• W2007257071 hasConcept C141035611 @default.
• W2007257071 hasConcept C142536801 @default.
• W2007257071 hasConcept C151730666 @default.
• W2007257071 hasConcept C151955695 @default.
• W2007257071 hasConcept C171089720 @default.
• W2007257071 hasConcept C17675752 @default.
• W2007257071 hasConcept C2777195935 @default.
• W2007257071 hasConcept C2779343474 @default.
• W2007257071 hasConcept C2780613262 @default.
• W2007257071 hasConcept C511355011 @default.
• W2007257071 hasConcept C55493867 @default.
• W2007257071 hasConcept C71924100 @default.
• W2007257071 hasConcept C86803240 @default.
• W2007257071 hasConcept C95444343 @default.
• W2007257071 hasConceptScore W2007257071C102230213 @default.
• W2007257071 hasConceptScore W2007257071C104317684 @default.
• W2007257071 hasConceptScore W2007257071C122927707 @default.
• W2007257071 hasConceptScore W2007257071C126322002 @default.
• W2007257071 hasConceptScore W2007257071C134018914 @default.
• W2007257071 hasConceptScore W2007257071C141035611 @default.
• W2007257071 hasConceptScore W2007257071C142536801 @default.
• W2007257071 hasConceptScore W2007257071C151730666 @default.
• W2007257071 hasConceptScore W2007257071C151955695 @default.
• W2007257071 hasConceptScore W2007257071C171089720 @default.
• W2007257071 hasConceptScore W2007257071C17675752 @default.
• W2007257071 hasConceptScore W2007257071C2777195935 @default.
• W2007257071 hasConceptScore W2007257071C2779343474 @default.
• W2007257071 hasConceptScore W2007257071C2780613262 @default.
• W2007257071 hasConceptScore W2007257071C511355011 @default.
• W2007257071 hasConceptScore W2007257071C55493867 @default.
• W2007257071 hasConceptScore W2007257071C71924100 @default.

• next