FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007259601> ?p ?o ?g. }

• W2007259601 endingPage "342" @default.
• W2007259601 startingPage "337" @default.
• W2007259601 abstract "Human serum paraoxonase (PON1) exists in 2 major polymorphic forms: Q (glutamine) or R (arginine) at codon 192. The PON1192 activity polymorphism is substrate dependent. The PON1Q192 isoform has a higher rate of in vitro hydrolysis of diazoxon, sarin, and soman, whereas the PON1R192 isoform has higher activity for the hydrolysis of paraoxon and chlorpyrifos oxon. Both isoforms hydrolyze phenyl acetate at approximately the same rate. The present study described and evaluated a kinetic method of arylesterase activity determination with a modified fixed incubation method that used the oxidative coupling of phenol with 4-aminoantipyrine of phenyl acetate as the substrate. Our improved method shows that arylesterase activity is lower with the PON1R192 isoform than with the PON1Q192 isoform. The average activities of serum of individuals of a specific PON1Q192 genotype showed higher arylesterase and lower paraoxonase activity than the PON1R192 genotype. The ratio of paraoxonase/arylesterase activity showed a clear separation of all three PON1192 genotypes with no overlap between the groups (QQ: < 5.0, QR: 5.0−11.0, RR: > 11.0). PCR has suggested that the PON1192 phenotypes correspond to the PON1192 genotypes. Therefore, when conducting epidemiological or mechanistic studies that examine the role of PON1 in organophosphorus or lipid metabolism, this ratio is more useful and informative than a PCR-based genotype alone." @default.
• W2007259601 created "2016-06-24" @default.
• W2007259601 creator A5009141118 @default.
• W2007259601 creator A5014352823 @default.
• W2007259601 creator A5021291521 @default.
• W2007259601 creator A5030673887 @default.
• W2007259601 creator A5035004421 @default.
• W2007259601 creator A5047761611 @default.
• W2007259601 creator A5049749258 @default.
• W2007259601 creator A5052563021 @default.
• W2007259601 creator A5073648533 @default.
• W2007259601 creator A5074124307 @default.
• W2007259601 date "2003-01-01" @default.
• W2007259601 modified "2023-09-30" @default.
• W2007259601 title "The Ratio of Serum Paraoxonase/Arylesterase Activity Using an Improved Assay for Arylesterase Activity to Discriminate PON1R192 from PON1Q192" @default.
• W2007259601 cites W1776082370 @default.
• W2007259601 cites W1874021135 @default.
• W2007259601 cites W1967607974 @default.
• W2007259601 cites W1968731162 @default.
• W2007259601 cites W1987622744 @default.
• W2007259601 cites W1997801947 @default.
• W2007259601 cites W2000665880 @default.
• W2007259601 cites W2007306216 @default.
• W2007259601 cites W2008378566 @default.
• W2007259601 cites W2008578311 @default.
• W2007259601 cites W2014723952 @default.
• W2007259601 cites W2015635131 @default.
• W2007259601 cites W2028915156 @default.
• W2007259601 cites W2036383576 @default.
• W2007259601 cites W2037335344 @default.
• W2007259601 cites W2048607595 @default.
• W2007259601 cites W2052751621 @default.
• W2007259601 cites W2074532601 @default.
• W2007259601 cites W2079453972 @default.
• W2007259601 cites W2079942839 @default.
• W2007259601 cites W2088622017 @default.
• W2007259601 cites W2092913820 @default.
• W2007259601 cites W2093420170 @default.
• W2007259601 cites W2099049551 @default.
• W2007259601 cites W2122385641 @default.
• W2007259601 cites W2129503890 @default.
• W2007259601 cites W2150545098 @default.
• W2007259601 cites W2397088274 @default.
• W2007259601 doi "https://doi.org/10.5551/jat.10.337" @default.
• W2007259601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15037822" @default.
• W2007259601 hasPublicationYear "2003" @default.
• W2007259601 type Work @default.
• W2007259601 sameAs 2007259601 @default.
• W2007259601 citedByCount "37" @default.
• W2007259601 countsByYear W20072596012012 @default.
• W2007259601 countsByYear W20072596012013 @default.
• W2007259601 countsByYear W20072596012014 @default.
• W2007259601 countsByYear W20072596012016 @default.
• W2007259601 countsByYear W20072596012017 @default.
• W2007259601 countsByYear W20072596012018 @default.
• W2007259601 countsByYear W20072596012019 @default.
• W2007259601 countsByYear W20072596012020 @default.
• W2007259601 countsByYear W20072596012021 @default.
• W2007259601 countsByYear W20072596012022 @default.
• W2007259601 countsByYear W20072596012023 @default.
• W2007259601 crossrefType "journal-article" @default.
• W2007259601 hasAuthorship W2007259601A5009141118 @default.
• W2007259601 hasAuthorship W2007259601A5014352823 @default.
• W2007259601 hasAuthorship W2007259601A5021291521 @default.
• W2007259601 hasAuthorship W2007259601A5030673887 @default.
• W2007259601 hasAuthorship W2007259601A5035004421 @default.
• W2007259601 hasAuthorship W2007259601A5047761611 @default.
• W2007259601 hasAuthorship W2007259601A5049749258 @default.
• W2007259601 hasAuthorship W2007259601A5052563021 @default.
• W2007259601 hasAuthorship W2007259601A5073648533 @default.
• W2007259601 hasAuthorship W2007259601A5074124307 @default.
• W2007259601 hasBestOaLocation W20072596011 @default.
• W2007259601 hasConcept C104317684 @default.
• W2007259601 hasConcept C135763542 @default.
• W2007259601 hasConcept C161176658 @default.
• W2007259601 hasConcept C181199279 @default.
• W2007259601 hasConcept C185592680 @default.
• W2007259601 hasConcept C2776509667 @default.
• W2007259601 hasConcept C2776588719 @default.
• W2007259601 hasConcept C2777207434 @default.
• W2007259601 hasConcept C2778242859 @default.
• W2007259601 hasConcept C2778816929 @default.
• W2007259601 hasConcept C2781389560 @default.
• W2007259601 hasConcept C37501387 @default.
• W2007259601 hasConcept C43617362 @default.
• W2007259601 hasConcept C53345823 @default.
• W2007259601 hasConcept C55493867 @default.
• W2007259601 hasConcept C6557445 @default.
• W2007259601 hasConcept C86803240 @default.
• W2007259601 hasConcept C94412978 @default.
• W2007259601 hasConceptScore W2007259601C104317684 @default.
• W2007259601 hasConceptScore W2007259601C135763542 @default.
• W2007259601 hasConceptScore W2007259601C161176658 @default.
• W2007259601 hasConceptScore W2007259601C181199279 @default.
• W2007259601 hasConceptScore W2007259601C185592680 @default.
• W2007259601 hasConceptScore W2007259601C2776509667 @default.
• W2007259601 hasConceptScore W2007259601C2776588719 @default.
• W2007259601 hasConceptScore W2007259601C2777207434 @default.

• next