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• W2007259715 abstract "Interleukin-6 (IL-6) is involved in inflammatory diseases, provides prognostical information, and allows the early identification and monitoring of septic patients. We investigated whether IL-6 can be assessed using a new densitometric point-of-care (POC) bedside assay.392 samples were prospectively collected from 57 intensive care unit patients (38 male, age: 45.2 +/- 16.9years, APACHE II score: 25.4 +/- 4.8). Blinded IL-6 measurements were performed using conventional semiautomatic enzyme-linked immunosorbent assays (ELISA) and the POC test.Mean IL-6 levels were 102.9 +/- 388.6pg/mL (ELISA) and 97.0 +/- 535.5 (POC). A significant correlation was found (p < 0.0001, r = 0.92). The sensitivity/specificity for sepsis was 82.6%/86.5% (ELISA, AUC: 0.881), and 76.4%/95.0% (POC, AUC: 0.868).Here we demonstrate significant correlations of IL-6 levels determined using a POC test and semiautomatic ELISA. ROC analyses revealed no significant differences between the two tests. With a turn-around time of 20min, the bedside IL-6 test is a new tool that may help to initiate early goal-directed therapy." @default.
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• W2007259715 date "2008-07-01" @default.
• W2007259715 modified "2023-10-18" @default.
• W2007259715 title "Interleukin-6 serum level assessment using a new qualitative point-of-care test in sepsis: A comparison with ELISA measurements" @default.
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• W2007259715 doi "https://doi.org/10.1016/j.clinbiochem.2008.03.008" @default.
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