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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007266738> ?p ?o ?g. }

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• W2007266738 abstract "The actions of agonists and antagonists of excitatory amino acid receptors were studied in the isolated ileal longitudinal muscle-myenteric plexus preparation of the guinea pig incubated 'in vitro', by recording the contraction of the longitudinal muscle. L-Glutamate, L-aspartate, quinolinate and N-methyl-D-aspartate (NMDA), in concentrations ranging from 10(-6) to 10(-4) M, induced a rapid contraction of this preparation while kainate and quisqualate were not active at a concentration of 10(-4) M. The excitatory amino acid responses were competitively antagonized by 2-amino-5-phosphonovalerate. They were also prevented by Mg2+ ions (0.1-1 mM), by tetrodotoxin 3 X 10(-6) M and by hyoscine 10(-7) M. The last observations suggest that the myenteric cholinergic interneurons are in some way involved in the glutamate-induced ileal contraction. These results demonstrate the existence of receptors for excitatory amino acids (possibly of NMDA type) in the myenteric plexus of the guinea pig." @default.
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• W2007266738 date "1986-07-01" @default.
• W2007266738 modified "2023-09-25" @default.
• W2007266738 title "The presence of N-methyl-d-aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus" @default.
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• W2007266738 doi "https://doi.org/10.1016/0304-3940(86)90229-6" @default.
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