FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007267205> ?p ?o ?g. }

• W2007267205 endingPage "e1001347" @default.
• W2007267205 startingPage "e1001347" @default.
• W2007267205 abstract "The inhibitory receptor programmed death-1 (PD-1) has the capacity to maintain peripheral tolerance and limit immunopathological damage; however, its precise role in fulminant viral hepatitis (FH) has yet to be described. Here, we investigated the functional mechanisms of PD-1 as related to FH pathogenesis induced by the murine hepatitis virus strain-3 (MHV-3). High levels of PD-1-positive CD4+, CD8+ T cells, NK cells and macrophages were observed in liver, spleen, lymph node and thymus tissues following MHV-3 infection. PD-1-deficient mice exhibited significantly higher expression of the effector molecule which initiates fibrinogen deposition, fibrinogen-like protein 2 (FGL2), than did their wild-type (WT) littermates. As a result, more severe tissue damage was produced and mortality rates were higher. Fluorescence double-staining revealed that FGL2 and PD-1 were not co-expressed on the same cells, while quantitative RT-PCR demonstrated that higher levels of IFN-γ and TNF-α mRNA transcription occurred in PD-1-deficient mice in response to MHV-3 infection. Conversely, in vivo blockade of IFN-γ and TNF-α led to efficient inhibition of FGL2 expression, greatly attenuated the development of tissue lesions, and ultimately reduced mortality. Thus, the up-regulation of FGL2 in PD-1-deficient mice was determined to be mediated by IFN-γ and TNF-α. Taken together, our results suggest that PD-1 signaling plays an essential role in decreasing the immunopathological damage induced by MHV-3 and that manipulation of this signal might be a useful strategy for FH immunotherapy." @default.
• W2007267205 created "2016-06-24" @default.
• W2007267205 creator A5006135866 @default.
• W2007267205 creator A5014054701 @default.
• W2007267205 creator A5020636129 @default.
• W2007267205 creator A5059961559 @default.
• W2007267205 creator A5064975207 @default.
• W2007267205 creator A5081511693 @default.
• W2007267205 creator A5089858384 @default.
• W2007267205 creator A5090810402 @default.
• W2007267205 date "2011-07-07" @default.
• W2007267205 modified "2023-09-23" @default.
• W2007267205 title "Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) Infection" @default.
• W2007267205 cites W1502553847 @default.
• W2007267205 cites W1621676818 @default.
• W2007267205 cites W1676372743 @default.
• W2007267205 cites W1699918302 @default.
• W2007267205 cites W1904944049 @default.
• W2007267205 cites W1934905808 @default.
• W2007267205 cites W1937712918 @default.
• W2007267205 cites W1950085922 @default.
• W2007267205 cites W1983270707 @default.
• W2007267205 cites W1983831001 @default.
• W2007267205 cites W1985225964 @default.
• W2007267205 cites W1997754215 @default.
• W2007267205 cites W2025741354 @default.
• W2007267205 cites W2035852466 @default.
• W2007267205 cites W2053607226 @default.
• W2007267205 cites W2055243308 @default.
• W2007267205 cites W2058798829 @default.
• W2007267205 cites W2061429827 @default.
• W2007267205 cites W2061883266 @default.
• W2007267205 cites W2063190888 @default.
• W2007267205 cites W2063463398 @default.
• W2007267205 cites W2066002010 @default.
• W2007267205 cites W2068029463 @default.
• W2007267205 cites W2070252617 @default.
• W2007267205 cites W2077605240 @default.
• W2007267205 cites W2097855813 @default.
• W2007267205 cites W2107277218 @default.
• W2007267205 cites W2108933323 @default.
• W2007267205 cites W2111143066 @default.
• W2007267205 cites W2121596012 @default.
• W2007267205 cites W2130506153 @default.
• W2007267205 cites W2131549241 @default.
• W2007267205 cites W2155464214 @default.
• W2007267205 cites W2170526373 @default.
• W2007267205 cites W269940620 @default.
• W2007267205 doi "https://doi.org/10.1371/journal.ppat.1001347" @default.
• W2007267205 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3131267" @default.
• W2007267205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21750671" @default.
• W2007267205 hasPublicationYear "2011" @default.
• W2007267205 type Work @default.
• W2007267205 sameAs 2007267205 @default.
• W2007267205 citedByCount "32" @default.
• W2007267205 countsByYear W20072672052012 @default.
• W2007267205 countsByYear W20072672052013 @default.
• W2007267205 countsByYear W20072672052014 @default.
• W2007267205 countsByYear W20072672052016 @default.
• W2007267205 countsByYear W20072672052017 @default.
• W2007267205 countsByYear W20072672052018 @default.
• W2007267205 countsByYear W20072672052019 @default.
• W2007267205 countsByYear W20072672052020 @default.
• W2007267205 countsByYear W20072672052021 @default.
• W2007267205 countsByYear W20072672052022 @default.
• W2007267205 crossrefType "journal-article" @default.
• W2007267205 hasAuthorship W2007267205A5006135866 @default.
• W2007267205 hasAuthorship W2007267205A5014054701 @default.
• W2007267205 hasAuthorship W2007267205A5020636129 @default.
• W2007267205 hasAuthorship W2007267205A5059961559 @default.
• W2007267205 hasAuthorship W2007267205A5064975207 @default.
• W2007267205 hasAuthorship W2007267205A5081511693 @default.
• W2007267205 hasAuthorship W2007267205A5089858384 @default.
• W2007267205 hasAuthorship W2007267205A5090810402 @default.
• W2007267205 hasBestOaLocation W20072672051 @default.
• W2007267205 hasConcept C142724271 @default.
• W2007267205 hasConcept C159047783 @default.
• W2007267205 hasConcept C167672396 @default.
• W2007267205 hasConcept C17991360 @default.
• W2007267205 hasConcept C203014093 @default.
• W2007267205 hasConcept C2779134260 @default.
• W2007267205 hasConcept C2779567548 @default.
• W2007267205 hasConcept C2780931953 @default.
• W2007267205 hasConcept C2780942790 @default.
• W2007267205 hasConcept C3008058167 @default.
• W2007267205 hasConcept C524204448 @default.
• W2007267205 hasConcept C71924100 @default.
• W2007267205 hasConcept C86803240 @default.
• W2007267205 hasConcept C8891405 @default.
• W2007267205 hasConceptScore W2007267205C142724271 @default.
• W2007267205 hasConceptScore W2007267205C159047783 @default.
• W2007267205 hasConceptScore W2007267205C167672396 @default.
• W2007267205 hasConceptScore W2007267205C17991360 @default.
• W2007267205 hasConceptScore W2007267205C203014093 @default.
• W2007267205 hasConceptScore W2007267205C2779134260 @default.
• W2007267205 hasConceptScore W2007267205C2779567548 @default.
• W2007267205 hasConceptScore W2007267205C2780931953 @default.
• W2007267205 hasConceptScore W2007267205C2780942790 @default.

• next