FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007269300> ?p ?o ?g. }

• W2007269300 abstract "Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity: PEPTIDES 17(6) 995-1002, 1996.-Systematic analysis of fragment derivatives of the superpotent alpha-MSH analogue. Ac-Ser.Tyr-Ser-Nle4-Glu- His-DPhe7-Arg-Trp-Gly-Lys-Pro-Val-NH2(NDP-MSH), led to the discovery of tripeptide agonists possessing prolonged bioactivity in the frog skin assay. Of particular significance to this discovery was Ac-DPhe-Arg-DTrp-NH2, which was the most potent tripeptide in this series exhibiting sustained melanotropic activity. Different pharmacophore models appear to exist that are dependent on the substructure and stereochemistry of the MSH(6-9) active site. The tripeptides Ac-DPhe-Arg-Trp-NH2, Ac-DPhe-Arg-DTrp-NH2, and Ac-DPhe-DArg-Trp-NH2 stereo-chemical combinations require only Phe7-Xaa8-Trp9, whereas Ac-DPhe-DArg-DTrp-NH2, Ac-Phe-Arg-DTrp-NH2, and Ac-Phe-Arg-Trp-NH2 additionally require His4 for minimal biological activity. Ac-DPhe-Arg-DTrp-NH2 represents a novel prototype lead for the development of MSH-based peptidomimetic agonists." @default.
• W2007269300 created "2016-06-24" @default.
• W2007269300 creator A5015964028 @default.
• W2007269300 creator A5046965421 @default.
• W2007269300 creator A5061416578 @default.
• W2007269300 creator A5071668584 @default.
• W2007269300 creator A5076760321 @default.
• W2007269300 creator A5076871613 @default.
• W2007269300 creator A5082655309 @default.
• W2007269300 creator A5087487462 @default.
• W2007269300 creator A5087721382 @default.
• W2007269300 creator A5089325140 @default.
• W2007269300 date "1996-10-02" @default.
• W2007269300 modified "2023-10-18" @default.
• W2007269300 title "Truncation Studies of ?-Melanotropin Peptides Identify Tripeptide Analogues Exhibiting Prolonged Agonist Bioactivity" @default.
• W2007269300 cites W1549372716 @default.
• W2007269300 cites W1566308385 @default.
• W2007269300 cites W1759002262 @default.
• W2007269300 cites W1770189426 @default.
• W2007269300 cites W1970716955 @default.
• W2007269300 cites W1974440984 @default.
• W2007269300 cites W1975109121 @default.
• W2007269300 cites W1978215242 @default.
• W2007269300 cites W1978709185 @default.
• W2007269300 cites W1979420492 @default.
• W2007269300 cites W1986798594 @default.
• W2007269300 cites W1990332976 @default.
• W2007269300 cites W1990492207 @default.
• W2007269300 cites W1996018952 @default.
• W2007269300 cites W2001411045 @default.
• W2007269300 cites W2011445167 @default.
• W2007269300 cites W2015370922 @default.
• W2007269300 cites W2021106556 @default.
• W2007269300 cites W2025871035 @default.
• W2007269300 cites W2027347113 @default.
• W2007269300 cites W2042639841 @default.
• W2007269300 cites W2042658226 @default.
• W2007269300 cites W2043997061 @default.
• W2007269300 cites W2045664576 @default.
• W2007269300 cites W2048464345 @default.
• W2007269300 cites W2048528168 @default.
• W2007269300 cites W2066655086 @default.
• W2007269300 cites W2078349465 @default.
• W2007269300 cites W2078711545 @default.
• W2007269300 cites W2081093272 @default.
• W2007269300 cites W2084547258 @default.
• W2007269300 cites W2084677170 @default.
• W2007269300 cites W2090460315 @default.
• W2007269300 cites W2091663002 @default.
• W2007269300 cites W2094828639 @default.
• W2007269300 cites W2144969564 @default.
• W2007269300 cites W2376870910 @default.
• W2007269300 cites W2889533537 @default.
• W2007269300 cites W560109847 @default.
• W2007269300 cites W605090603 @default.
• W2007269300 cites W83286027 @default.
• W2007269300 doi "https://doi.org/10.1016/s0196-9781(96)00141-6" @default.
• W2007269300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8899819" @default.
• W2007269300 hasPublicationYear "1996" @default.
• W2007269300 type Work @default.
• W2007269300 sameAs 2007269300 @default.
• W2007269300 citedByCount "28" @default.
• W2007269300 countsByYear W20072693002015 @default.
• W2007269300 countsByYear W20072693002016 @default.
• W2007269300 countsByYear W20072693002017 @default.
• W2007269300 countsByYear W20072693002021 @default.
• W2007269300 crossrefType "journal-article" @default.
• W2007269300 hasAuthorship W2007269300A5015964028 @default.
• W2007269300 hasAuthorship W2007269300A5046965421 @default.
• W2007269300 hasAuthorship W2007269300A5061416578 @default.
• W2007269300 hasAuthorship W2007269300A5071668584 @default.
• W2007269300 hasAuthorship W2007269300A5076760321 @default.
• W2007269300 hasAuthorship W2007269300A5076871613 @default.
• W2007269300 hasAuthorship W2007269300A5082655309 @default.
• W2007269300 hasAuthorship W2007269300A5087487462 @default.
• W2007269300 hasAuthorship W2007269300A5087721382 @default.
• W2007269300 hasAuthorship W2007269300A5089325140 @default.
• W2007269300 hasConcept C13935069 @default.
• W2007269300 hasConcept C167392928 @default.
• W2007269300 hasConcept C170493617 @default.
• W2007269300 hasConcept C185592680 @default.
• W2007269300 hasConcept C2778938600 @default.
• W2007269300 hasConcept C2779281246 @default.
• W2007269300 hasConcept C2779564779 @default.
• W2007269300 hasConcept C55493867 @default.
• W2007269300 hasConcept C56173144 @default.
• W2007269300 hasConcept C71240020 @default.
• W2007269300 hasConceptScore W2007269300C13935069 @default.
• W2007269300 hasConceptScore W2007269300C167392928 @default.
• W2007269300 hasConceptScore W2007269300C170493617 @default.
• W2007269300 hasConceptScore W2007269300C185592680 @default.
• W2007269300 hasConceptScore W2007269300C2778938600 @default.
• W2007269300 hasConceptScore W2007269300C2779281246 @default.
• W2007269300 hasConceptScore W2007269300C2779564779 @default.
• W2007269300 hasConceptScore W2007269300C55493867 @default.
• W2007269300 hasConceptScore W2007269300C56173144 @default.
• W2007269300 hasConceptScore W2007269300C71240020 @default.
• W2007269300 hasLocation W20072693001 @default.
• W2007269300 hasLocation W20072693002 @default.
• W2007269300 hasOpenAccess W2007269300 @default.

• next