Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007269310> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2007269310 endingPage "743" @default.
- W2007269310 startingPage "737" @default.
- W2007269310 abstract "In order to detect the portion of the angiotensin II molecule binding to the human arteriolar receptor, angiotensine II-(1-5)-pentapeptide, angiotensin II-(1-4)-tetrapeptide and angiotensin II-(1-3)-tripeptide were infused intravenously as saline solutions into the same 5 normal men from 0900 h at a rate of 30 nmol (20 μg)/kg min (1.2 ml/min) for 15 minutes, at a rate of 90 nmol (54.5μg)/kg·min (3.0ml/ min) for 6 minutes and at a rate of 140 nmol (54.5μg)/ kg· min (3.0 ml/ min) for 6 minutes, respectively, on different occasions. At the end of the infusions average increases in blood pressure were 20/22 mmHg (p<0.001) and 6/7 mmHg (p<0.001), respectively, with the former 2 peptides, while the last peptide showed no pressor action at all. It had previously been found by our research group that angiotensin III, angiotensin II-(3-8)-hexapeptide, angiotensin II-(4-8)-pentapeptide, angiotensin II-(2-7)-hexapeptide, angiotensin II-(1-7)-heptapeptide and angiotensin II-(1-6)-hexapeptide have some pressor action but that angiotensin II-(5-8)-tetrapptide has no pressor action in normal men. When these previous results are combined with the present result, it is evident that only tyrosine-containing molecules show pressor activity and that tyrosine-deleted molecules do not show pressor activity at all. It is concluded that tyrosine in position 4 is the key amino acid for the binding of angiotensin II to human arteriolar receptor." @default.
- W2007269310 created "2016-06-24" @default.
- W2007269310 creator A5006557735 @default.
- W2007269310 creator A5008125686 @default.
- W2007269310 creator A5043021883 @default.
- W2007269310 creator A5079175100 @default.
- W2007269310 date "1987-01-01" @default.
- W2007269310 modified "2023-09-26" @default.
- W2007269310 title "Tyrosine in Position 4 Is The Key Amino Acid for The Binding of Angiotensin II to Human Arteriolar Receptor." @default.
- W2007269310 cites W150227162 @default.
- W2007269310 cites W167941257 @default.
- W2007269310 cites W1870082994 @default.
- W2007269310 cites W1968580526 @default.
- W2007269310 cites W1987132877 @default.
- W2007269310 cites W2029456335 @default.
- W2007269310 cites W2037777700 @default.
- W2007269310 cites W2063470522 @default.
- W2007269310 cites W2088950847 @default.
- W2007269310 cites W2117594247 @default.
- W2007269310 cites W2127736042 @default.
- W2007269310 cites W2279305605 @default.
- W2007269310 cites W2066571397 @default.
- W2007269310 doi "https://doi.org/10.1507/endocrj1954.34.737" @default.
- W2007269310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3436303" @default.
- W2007269310 hasPublicationYear "1987" @default.
- W2007269310 type Work @default.
- W2007269310 sameAs 2007269310 @default.
- W2007269310 citedByCount "5" @default.
- W2007269310 crossrefType "journal-article" @default.
- W2007269310 hasAuthorship W2007269310A5006557735 @default.
- W2007269310 hasAuthorship W2007269310A5008125686 @default.
- W2007269310 hasAuthorship W2007269310A5043021883 @default.
- W2007269310 hasAuthorship W2007269310A5079175100 @default.
- W2007269310 hasBestOaLocation W20072693101 @default.
- W2007269310 hasConcept C104849204 @default.
- W2007269310 hasConcept C123915805 @default.
- W2007269310 hasConcept C126322002 @default.
- W2007269310 hasConcept C134018914 @default.
- W2007269310 hasConcept C167392928 @default.
- W2007269310 hasConcept C170493617 @default.
- W2007269310 hasConcept C185592680 @default.
- W2007269310 hasConcept C198710026 @default.
- W2007269310 hasConcept C2776165026 @default.
- W2007269310 hasConcept C2779281246 @default.
- W2007269310 hasConcept C2779564779 @default.
- W2007269310 hasConcept C2908560794 @default.
- W2007269310 hasConcept C2908929049 @default.
- W2007269310 hasConcept C45197812 @default.
- W2007269310 hasConcept C515207424 @default.
- W2007269310 hasConcept C55493867 @default.
- W2007269310 hasConcept C71924100 @default.
- W2007269310 hasConcept C84393581 @default.
- W2007269310 hasConcept C86803240 @default.
- W2007269310 hasConceptScore W2007269310C104849204 @default.
- W2007269310 hasConceptScore W2007269310C123915805 @default.
- W2007269310 hasConceptScore W2007269310C126322002 @default.
- W2007269310 hasConceptScore W2007269310C134018914 @default.
- W2007269310 hasConceptScore W2007269310C167392928 @default.
- W2007269310 hasConceptScore W2007269310C170493617 @default.
- W2007269310 hasConceptScore W2007269310C185592680 @default.
- W2007269310 hasConceptScore W2007269310C198710026 @default.
- W2007269310 hasConceptScore W2007269310C2776165026 @default.
- W2007269310 hasConceptScore W2007269310C2779281246 @default.
- W2007269310 hasConceptScore W2007269310C2779564779 @default.
- W2007269310 hasConceptScore W2007269310C2908560794 @default.
- W2007269310 hasConceptScore W2007269310C2908929049 @default.
- W2007269310 hasConceptScore W2007269310C45197812 @default.
- W2007269310 hasConceptScore W2007269310C515207424 @default.
- W2007269310 hasConceptScore W2007269310C55493867 @default.
- W2007269310 hasConceptScore W2007269310C71924100 @default.
- W2007269310 hasConceptScore W2007269310C84393581 @default.
- W2007269310 hasConceptScore W2007269310C86803240 @default.
- W2007269310 hasIssue "5" @default.
- W2007269310 hasLocation W20072693101 @default.
- W2007269310 hasLocation W20072693102 @default.
- W2007269310 hasOpenAccess W2007269310 @default.
- W2007269310 hasPrimaryLocation W20072693101 @default.
- W2007269310 hasRelatedWork W1966128948 @default.
- W2007269310 hasRelatedWork W1989591433 @default.
- W2007269310 hasRelatedWork W2007269310 @default.
- W2007269310 hasRelatedWork W2073203285 @default.
- W2007269310 hasRelatedWork W2118736985 @default.
- W2007269310 hasRelatedWork W2126797993 @default.
- W2007269310 hasRelatedWork W2132612653 @default.
- W2007269310 hasRelatedWork W2272080549 @default.
- W2007269310 hasRelatedWork W2397870085 @default.
- W2007269310 hasRelatedWork W2412417271 @default.
- W2007269310 hasVolume "34" @default.
- W2007269310 isParatext "false" @default.
- W2007269310 isRetracted "false" @default.
- W2007269310 magId "2007269310" @default.
- W2007269310 workType "article" @default.