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- W2007271622 abstract "Liver disease is a common, often complex complication of allogeneic hematopoietic stem cell transplantation (HSCT) with multi-factorial etiology. Accurate diagnosis is typically made using a combination of clinical, laboratory and radiological data, assisted by a knowledge of risk factors for particular liver disease. To evaluate the safety and utility of liver biopsy in this population, we reviewed data of 45 allogeneic HSCT and donor lymphocyte infusion (DLI) recipients who underwent liver biopsy for hepatic dysfunction of unclear etiology from 1995 to 2006. Seven patients had the procedure performed more than once, yielding a total number of 55 studies. Time to liver biopsy and liver function studies prior to the procedure were analyzed with patient characteristics depicted in the table below. As a result of this procedure, graft versus host disease (GVHD) was confirmed in 23/49 (47%) of suspected cases and sinusoidal obstructive syndrome (SOS) was confirmed in 1/3 (33%) of suspected cases. Similarly, infection and disease relapse were present in only 33% and 29% of suspected cases, respectively. Drug toxicity, however, was confirmed in 12/20 (60%) of suspected cases. The procedure was helpful in modifying or continuing current therapy in 40% of the cases. A total of 13% of the procedures had associated complications including capsular perforation with fatal hemorrhage (n = 2, 4%). While not without risk, liver biopsy findings confirmed or refuted the clinical diagnosis in 60% of cases. This information was used to modify therapy in 40% of cases. Whether the risk of liver biopsy is justified by the benefit of therapeutic change remains to be demonstrated by further investigation.Table 1Patient CharacteristicsPatientsn = 45Mean age (range)42.8 (20-64)Sex (M/F)32/13DiseaseALL4 (9%)AML7 (16%)CML9 (20%)Hodgkin's Lymphoma4 (9%)Non-Hodgkin's Lymphoma13 (29%)MDS7 (16%)Multiple Myeloma1 (2%)ALL indicates Acute Lymphocytic Leukemia, AML: Acute Myelogenous Leukemia; CML: Chronic Myeloid Leukemia; MDS: Myelodysplastic Syndrome Open table in a new tab" @default.
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- W2007271622 date "2011-02-01" @default.
- W2007271622 modified "2023-10-14" @default.
- W2007271622 title "Safety and Utility of Liver Biopsy in Allogeneic Hematopoietic Stem Cell Transplant Recipients With Liver Dysfunction" @default.
- W2007271622 doi "https://doi.org/10.1016/j.bbmt.2010.12.450" @default.
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