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- W2007272010 abstract "Mutant cell lines have been selected from the murine plasmocytoma MOPC 173 for their resistance to ouabain, dibutyryl cyclic AMP, theophyllin and concanavalin A. We have compared three wild-type cell lines with their seven resistant counterparts. All resistant mutants exhibited a (Na+ + K+)-stimulated Mg2+-ATPase resistance to ouabain inhibition when measured in microsomes. The homogeneity of ouabain binding sites has been found in most of the cell lines; however, two different populations of sites have been detected in one wild-type and in one resistant cell lines. These results led us to hypothetise the (Na+ + K+)-ATPase-ouabain interaction being modulated by a non-specific membrane structure." @default.
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- W2007272010 date "1976-12-01" @default.
- W2007272010 modified "2023-09-27" @default.
- W2007272010 title "Plasma membrane studies on drug-sensitive and resistant cell lines. II. Ouabain sensitivity of (Na+ + K+)-stimulated Mg2+-ATPase" @default.
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- W2007272010 doi "https://doi.org/10.1016/0005-2736(76)90304-7" @default.
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