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• W2007272202 abstract "The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation. Caffeine, over a range of dosages, showed limited embryotoxic activity. Phenytoin was also weakly teratogenic and dosages needed to elicit embryotoxicity were accompanied by a significant increase in maternal lethality. Pretreatment with caffeine enhanced phenytoin-induced toxicity and teratogenicity and these observations confirm that caffeine has the ability to function as a co-teratogen. Pretreatment with phenytoin produced a significant increase in maternal lethality following caffeine administration but no co-teratogenic effect. It is suggested that these results are the consequence of a yet undefined interaction at critical receptor sites in the maternal-embryo unit." @default.
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• W2007272202 date "1984-02-01" @default.
• W2007272202 modified "2023-09-27" @default.
• W2007272202 title "The toxicology of chemical interactions during pregnancy in the mouse: Caffeine and phenytoin" @default.
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• W2007272202 doi "https://doi.org/10.1016/0300-483x(84)90057-x" @default.
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